Gut metagenomes in Alzheimer's disease case-control study
52 fecal samples (26 from AD patients matched for gender and age, 26 from healthy controls), analyzed by Nanopore metagenomic sequencing in a case-control design; country/location not specified. machine-written summary
52 samples · 52 runs · Age unknown · 2026 · 0.34 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 156 sample values (collection date, health condition, health condition detail) |
| ✓ Abstract / description | 52 sample values (subject id) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 0 | 0% | ||||
| health_condition | 52 | 100% | 52 | |||
| subject_id | 52 | 100% | 52 | |||
| collection_date | 52 | 100% | 52 | |||
| health_condition_detail | 52 | 100% | 52 |
- Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis 2025 PMID 39510074 own_data
Archive description
To explore alterations in the gut microbiota of individuals with Alzheimer's disease (AD), we collected 26 fecal samples from AD patients, matched for gender and age, as well as 26 samples from healthy controls. DNA was extracted from these samples and subjected to Nanopore third-generation sequencing. Using metagenomics methods to analyze.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.70. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.description · “we collected 26 fecal samples from AD patients”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMD01708961 | collection_date | 2022-09-18 | R1 | 0.90 | biosample.attribute:collection_date | 2022-09-18 |
| SAMD01708961 | health_condition | neurological_psychiatric | R1 | 0.70 | sample.name_rule:sample_name | SAMC3112495_AD1 |
| SAMD01708961 | health_condition_detail | AD | R1 | 0.70 | sample.name_rule:sample_name | SAMC3112495_AD1 |
| SAMD01708961 | subject_id | SAMD01708961 | R4 | 0.60 | design.one_sample_per_subject:description | we collected 26 fecal samples from AD patients, matched for gender and age, as well as 26 samples from healthy controls |
Sequencing
52 runs over 52 samples · mean 0.35 Gbp per run (median 0.34 Gbp, total 18.19 Gbp; 52 runs with a base count) · layout SINGLE 52 · platform OXFORD_NANOPORE 52 · models MinION (52) · 0% of runs with a Sandpiper profile · first public 2026-06-02
Authors (12)
Zha X first · Liu X · Wei M · Huang H · Cao J · Liu S · Bian X · Zhang Y · Xiao F · Xie Y · Wang W · Zhang C last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, country. Share metadata
Downloads
PRJDB29433.csv.gz (2.2 KB) · parquet (71.2 KB) — all 52 samples, every field with route and confidence · PRJDB29433_determinations.csv.gz (2.7 KB) — 208 evidence rows