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PRJDB37437 DRP017698

Gut microbiome in IgA and membranous nephropathy, case-control

Integrated Metagenomic and Metabolomic Profiling Reveals Gut Microbiota Dysbiosis and Metabolic Dysregulation in IgA Nephropathy and Membranous Nephropathy (PRJCA039250)

61 samples from a case-control study comparing gut microbiota and metabolomic profiles among IgA nephropathy patients, membranous nephropathy patients, and healthy controls; sample location not reported. machine-written summary

61 samples · 61 runs · CN · Age unknown · 2026 · 6.41 Gbp / sample

Sources
✓Sequence archive 61○Abstract / description✓Full text 122○Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive61 sample values (collection date)
○ Abstract / descriptionread; no usable statement
✓ Full text122 sample values (country, subject id) · PMC12307357
○ Supplementary tablesfiles read; no table could be matched to the samples
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet · share metadata
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 country
Age
unknown61
Country
CN61
Body site
primary61
Collected 2023–2024
2023: 32 samples2024: 29 samples20232024
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 61 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 6.41 Gbp per sample0130Gbp
Community composition

No Sandpiper profile for this project's samples yet.

Field coverage
fieldsamplescoverageR1R2R3R4
age_category0 0%
country61 100%61
health_condition0 0%
subject_id61 100%61
collection_date61 100%61
Papers (1)
  • The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy. 2025 PMID 40740937 PMC12307357 own_data
Details
Archive description

Immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) are primary glomerular diseases with increasing incidence, yet their pathogenesis and non-invasive diagnostic approaches remain insufficiently understood. In this study, we integrated metagenomic and untargeted metabolomic profiling to explore gut microbiota alterations and metabolic disturbances in 24 IgAN patients, 20 MN patients, and 17 healthy controls.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.68. Assay shotgun_dna.

  • host run.scientific_name · “human gut metagenome”
  • body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMD01841713collection_date2024-04-15R10.90biosample.attribute:collection_date2024-04-15
SAMD01841713countryCNR30.70paper.body.methods_resultsA total of 61 subjects from Guang’an First People’s Hospital, Sichuan Province, China, were enrolled in this study.
SAMD01841713subject_idSAMD01841713R30.70design.one_sample_per_subject:fulltextA total of 61 subjects from Guang’an First People’s Hospital, Sichuan Province, China, were enrolled
Sequencing

61 runs over 61 samples · mean 6.52 Gbp per run (median 6.41 Gbp, total 397.43 Gbp; 61 runs with a base count) · layout PAIRED 61 · platform ILLUMINA 61 · models Illumina NovaSeq 6000 (61) · 0% of runs with a Sandpiper profile · first public 2026-06-02

Authors (0)

No author record.

Help complete this project

2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata

Downloads

PRJDB37437.csv.gz (2.6 KB) · parquet (71.4 KB) — all 61 samples, every field with route and confidence · PRJDB37437_determinations.csv.gz (2.2 KB) — 183 evidence rows

Samples (61 · every field this project has values for · hover a cell for its source)
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