Gut microbiota in MDD with/without IBS vs controls
Case-control study of 118 gut microbiome samples comparing major depressive disorder patients (with and without comorbid IBS) to healthy controls; location not specified in the curated facts. machine-written summary
119 samples · 119 runs · Age unknown · 2026 · 6.55 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 118 sample values (collection date) |
| ✓ Abstract / description | 119 sample values (health condition detail) |
| ○ Full text | read; no usable statement or table · PMC12607870 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 0 | 0% | ||||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| health_condition_detail | 119 | 100% | 119 | |||
| collection_date | 118 | 99% | 118 |
- Gut microbiota dysbiosis and metabolic perturbations of bile/glyceric acids in major depressive disorder with IBS comorbidity. 2025 PMID 41055380 PMC12607870 own_data
Archive description
Major depressive disorder (MDD) and irritable bowel syndrome (IBS) exhibit high comorbidity, yet their shared pathophysiology remains unclear. Previous studies have primarily focused on the psychological health in the IBS population, without considering psychiatric diagnoses or stratifying different psychological states, potentially leading to biased findings.This study employed multi-omics approaches to characterize gut microbiota and serum metabolites in MDD patients ( with IBS, without IBS) and healthy controls (HC).
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.75. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMD01842862 | collection_date | 2021-07-16 | R1 | 0.90 | biosample.attribute:collection_date | 2021-07-16 |
| SAMD01842862 | health_condition_detail | mixed_case_control: Major depressive disorder patients (with and without IBS comorbidity) vs healthy controls. | R4 | 0.40 | study.description | MDD patients ( with IBS, without IBS) and healthy controls (HC) |
Sequencing
119 runs over 119 samples · mean 6.52 Gbp per run (median 6.55 Gbp, total 776.03 Gbp; 119 runs with a base count) · layout PAIRED 119 · platform ILLUMINA 119 · models Illumina NovaSeq 6000 (119) · 0% of runs with a Sandpiper profile · first public 2026-06-02
Authors (0)
No author record.
Help complete this project
4 of the 4 core fields are below 50% coverage: age_category, country, health_condition, subject_id. Share metadata
Downloads
PRJDB41212.csv.gz (3.9 KB) · parquet (74.2 KB) — all 119 samples, every field with route and confidence · PRJDB41212_determinations.csv.gz (2.3 KB) — 237 evidence rows