GLP-1 agonist vs dietary fiber in overweight/obese adults
112 samples from an open-label, multi-centered clinical trial comparing GLP-1 receptor agonist (semaglutide) and high dietary fiber interventions in overweight or obese subjects; related mouse FMT and dietary experiments were also conducted. machine-written summary
142 samples · 217 runs · Age unknown · 2026 · 10.17 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 142 sample values (collection date) |
| ✓ Abstract / description | 142 sample values (health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin Prebiotic / dietary fibre supplement design randomized_controlled_trial · population obesity · Semaglutide (GLP-1 RA) vs high dietary fiber in obese subjects; FMT to germ-free mice
“GLP-1 receptor agonists or high dietary fiber interventions study” — bioproject.description (study level; per-sample arms are in the intervention column below)
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 0 | 0% | ||||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 142 | 100% | 142 | |||
| health_condition_detail | 142 | 100% | 142 |
- GLP-1 RA-Exacerbated Gut Microbiome Dysbiosis in Obesity Mediates Post-Cessation Weight Regain 2026 own_data
Archive description
The GLP-1 receptor agonists or high dietary fiber interventions study is an open-label, multi-centered clinical trial in subjects with overweight or obese. FMT animal trial: The six-week-old germ-free male mice (C57BL/6J) were given oral gavage (3 times/week) with a 200-�l fecal slurry for 2 weeks. Mice were randomly divided into two groups: mW and mG groups (n=15 per group) inoculated with the fecal slurry of two donors who are from W (dietary fiber intervention) and G (semaglutide intervention) groups, respectively. Semaglutide and dietary fiber interventions animal trial: The eight-week-old SPF male mice (C57BL/6J) were fed western style diet (D12079B, SYSE Bio-tech. Co., Ltd., China) for 4 weeks to construct diet-induced obesity (DIO) model, then performed once every three days subcutaneous injection with semaglutide (0.1 mg/kg body weight, GWSD group) or semaglutide and oral gavage of dietary fiber (500 mg/kg bodyweight/day, WGWSD group) or normal saline as control (CWSD group) for 4 weeks. After the intervention, the mice of GWSD group and WGWSD group were fed normal chow diet (AIN-93G, SYSE Bio-tech. Co., Ltd., China) for 3 weeks as GNC group and WGNC group, respectively.
How this project entered the registry
Classified as human and non-human (mixed) gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.40. Assay shotgun_dna.
- host study.description · “clinical trial in subjects with overweight or obese”
- host study.description · “germ-free male mice (C57BL/6J)”
- body site study.description · “200-�l fecal slurry”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMD01844202 | collection_date | 2023-01-13 | R1 | 0.90 | biosample.attribute:collection_date | 2023-01-13 |
| SAMD01844202 | health_condition_detail | mixed_case_control: dietary fiber vs semaglutide intervention groups | R4 | 0.50 | study.description | subjects with overweight or obese |
Sequencing
217 runs over 142 samples · mean 7.12 Gbp per run (median 10.17 Gbp, total 1,544.49 Gbp; 217 runs with a base count) · layout PAIRED 217 · platform ILLUMINA 217 · models Illumina NovaSeq 6000 (138), Illumina HiSeq 2000 (79) · 0% of runs with a Sandpiper profile · first public 2026-06-02
Authors (0)
No author record.
Help complete this project
4 of the 4 core fields are below 50% coverage: age_category, country, health_condition, subject_id. Share metadata
Downloads
PRJDB41627.csv.gz (4.3 KB) · parquet (74.4 KB) — all 142 samples, every field with route and confidence · PRJDB41627_determinations.csv.gz (2.5 KB) — 284 evidence rows