Stool metagenomes in Crohn's disease patients on biologics
89 adult stool samples from patients with Crohn's disease receiving biologic therapies, in an intervention study of treatment-associated microbial signatures linked to clinical and biochemical remission. machine-written summary
89 samples · 89 runs · IL · Adult · 2026 · 3.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 356 sample values (country, health condition, health condition detail, subject id) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design observational_with_procedure · population crohns_disease · Biologic therapies for Crohn's disease, treatment-associated signatures
“patients with Crohn's disease receiving biologic therapies” — bioproject.description (study level; per-sample arms are in the intervention column below)
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 89 | 100% | ||||
| country | 89 | 100% | 89 | |||
| health_condition | 89 | 100% | 89 | |||
| subject_id | 89 | 100% | 89 | |||
| health_condition_detail | 89 | 100% | 89 |
Archive description
This project comprises shotgun metagenomic sequencing of stool samples from 89 patients with Crohn's disease receiving biologic therapies. The dataset was generated to characterize the gut microbiome and to investigate treatment-associated microbial signatures and their association with composite clinical and biochemical remission.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Stool shotgun metagenomes from”
- body site study.description · “metagenomic sequencing of stool samples from 89”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMD01962613 | country | IL | R1 | 0.90 | sample.attr.geo_loc_name | Israel |
| SAMD01962613 | health_condition | crohns_disease | R1 | 0.90 | biosample_attr | Crohn's disease |
| SAMD01962613 | health_condition_detail | Crohn's disease | R1 | 0.90 | sample.attr.host_disease | Crohn's disease |
| SAMD01962613 | subject_id | F-AA-19113 | R1 | 0.85 | sample.attr.host_subject_id | F-AA-19113 |
Sequencing
89 runs over 89 samples · mean 3.56 Gbp per run (median 3.14 Gbp, total 316.97 Gbp; 89 runs with a base count) · layout PAIRED 89 · platform ILLUMINA 89 · models Illumina NovaSeq X (89) · 0% of runs with a Sandpiper profile · first public 2026-09-10
Authors (0)
No author record.
Downloads
PRJDB43083.csv.gz (3.6 KB) · parquet (73.8 KB) — all 89 samples, every field with route and confidence · PRJDB43083_determinations.csv.gz (2.8 KB) — 356 evidence rows