FMT for diabetic peripheral neuropathy, China (88 samples)
88 fecal metagenome samples from patients in China with diabetic peripheral neuropathy, studying fecal microbiota transplantation versus placebo in an intervention trial design. machine-written summary
88 samples · 88 runs · CN · Age unknown · 2022 · 9.13 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 432 sample values (collection date, country, latitude, longitude, subject id) |
| ✓ Abstract / description | 88 sample values (health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation design randomized_controlled_trial · population type2_diabetes · FMT from healthy donors via mid-gut vs placebo for diabetic peripheral neuropathy
“using fecal microbiota transplantation (FMT) from the healthy donors” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolvedFMT donor → recipient — not resolved
17 of 19 people sampled more than once (78 samples; median 5, up to 5 per person). Schedule stated by the source: “stool at D0, D3, 4 weeks, 8 weeks, and 12 weeks post-FMT” (time origin: intervention start); stated follow-up 3 mo.
FMT for diabetic neuropathy; donor stool samples deposited (e.g. FMT018-Donor) but donor–recipient pairing not stated.
Genera, mean relative abundance over 82 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 88 | 100% | 88 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 80 | 91% | 80 | |||
| collection_date | 88 | 100% | 88 | |||
| health_condition_detail | 88 | 100% | 88 | |||
| latitude | 88 | 100% | 88 | |||
| longitude | 88 | 100% | 88 |
- Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes. 2023 PMID 37451270 own_data
Archive description
Diabetic peripheral neuropathy (DPN) is one of the serious and long-term complications of diabetes mellitus, which has no modifiable treatment. Here we reported the results of using fecal microbiota transplantation (FMT) from the healthy donors as a therapeutic alternative for patients with DPN. Compared to the patients received placebo, the patients with FMT via mid-gut showed significant alleviation of the function of sensory and motor nerves after 12 weeks, accompanying with improvement of the gut barrier integrity and decrease of proinflammatory cytokines. The metagenomic sequencing data suggested that the gut microbiota in patients after FMT had higher capacity to produce butyrate and decreased the biosynthesis of endotoxin. Thus, our work provides the feasibility of using FMT to treatment for DPN.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.72. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMD00218050 | collection_date | 2018 | R1 | 0.90 | biosample.attribute:collection_date | 2018 |
| SAMD00218050 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMD00218050 | health_condition_detail | mixed_case_control: DPN patients (FMT-treated) vs placebo controls | R4 | 0.50 | study.description | patients received placebo, the patients with FMT |
| SAMD00218050 | latitude | 24.7000 | R1 | 0.90 | biosample.attribute:lat_lon | 24.7 N 113.6 E |
| SAMD00218050 | longitude | 113.6000 | R1 | 0.90 | biosample.attribute:lat_lon | 24.7 N 113.6 E |
| SAMD00218050 | subject_id | 003 | R1 | 0.70 | sample.name_rule:sample_name | D003-10-31 |
Sequencing
88 runs over 88 samples · mean 9.54 Gbp per run (median 9.13 Gbp, total 839.89 Gbp; 88 runs with a base count) · layout PAIRED 88 · platform ILLUMINA 88 · models Illumina HiSeq 3000 (88) · 93% of runs with a Sandpiper profile · first public 2022-04-11
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJDB9649.csv.gz (2.9 KB) · parquet (73.1 KB) — all 88 samples, every field with route and confidence · PRJDB9649_determinations.csv.gz (3.8 KB) — 520 evidence rows