Diet, anxiety and gut microbiome in young UK women
Cross-sectional study of 43 gut metagenome samples from young adult women (18–24 years) in the United Kingdom, examining associations between diet quality, gut microbiome composition, and subclinical anxiety (STAI-s). machine-written summary
43 samples · 44 runs · GB · Adult · 2025 · 9.23 Gbp / sample · cohort Anxiety associated with dietary intake and gut mic
One study deposited as 2 BioProjects (123 catalog samples together): PRJEB105368 · PRJEB112777 · show together
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 215 sample values (collection date, country, latitude, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 42 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 43 | 100% | ||||
| country | 43 | 100% | 43 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 43 | 100% | 43 | |||
| detailed_location | 43 | 100% | ||||
| latitude | 43 | 100% | 43 | |||
| location_region | 43 | 100% | 43 | |||
| longitude | 43 | 100% | 43 |
- Anxiety associated with dietary intake and gut microbiome features in a cross-sectional cohort of sub-clinically anxious young women 2026 own_data
Archive description
Emerging evidence highlights the gut-brain axis as a key pathway linking diet and anxiety, but the specific dietary and gut microbiome drivers remain unclear. In this study, we investigated associations between dietary intake, gut microbiome composition, and anxiety in a subclinical cohort of 46 females (18–24 years) from the United Kingdom. Long-term diet quality was assessed using the Healthy Eating Index (HEI-2020) derived from a food frequency questionnaire, stratifying participants into lower and higher diet quality clusters. Short-term dietary intake was assessed via 24-hour recalls. Shotgun metagenomics of stool samples was used to assees differences in α and β diversity indices, species abundances, and bacterial pathways putatively metabolizing gut-brain-axis relevant molecules. Anxiety was measured using the State–Trait Anxiety Inventory (state subscale – STAI-s). Regression models identified diet quality (HEI cluster) as the primary dietary feature of anxiety variation. The presence of Ruminococcus B gnavus and Flavonifractor plautii, and the abundances of several species were positively associated with STAI-s, with Bilophila wadsworthia explaining 40% of its variance. The presence of Feacalibacterium prausnitzii and greater abundances of butyrate, propionate, and GABA synthesis pathways were inversely associated with anxiety. Non-linear models revealed a U-shaped relationship between inositol synthesis and STAI-s. Finally, we found that habitual diet quality may modulate anxiety-related responses to short-term dietary variation. These findings reveal widespread links between long-term diet quality, microbiota composition and function, and anxiety symptoms. These results point towards several promising targets for prebiotic, probiotic, postbiotic, and dietary interventions targets aimed at reducing anxiety.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “dietary intake and gut microbiome features in”
- body site study.description · “evidence highlights the gut -brain axis as”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.title · “sub-clinically anxious young women .”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA120821613 | collection_date | 2024 | R1 | 0.90 | biosample.attribute:collection_date | 2024 |
| SAMEA120821613 | country | GB | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | United Kingdom |
| SAMEA120821613 | latitude | 51.2400 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 51.24 -0.59 |
| SAMEA120821613 | location_region | England | R1 | 0.60 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 51.24 -0.59 |
| SAMEA120821613 | longitude | -0.5900 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 51.24 -0.59 |
Sequencing
44 runs over 43 samples · mean 9.09 Gbp per run (median 9.18 Gbp, total 399.93 Gbp; 44 runs with a base count) · layout PAIRED 44 · platform ILLUMINA 44 · models Illumina NovaSeq 6000 (44) · 95% of runs with a Sandpiper profile · first public 2025-12-23 – 2026-05-15
Authors (0)
No author record.
Downloads
PRJEB105368.csv.gz (1.9 KB) · parquet (70.5 KB) — all 43 samples, every field with route and confidence · PRJEB105368_determinations.csv.gz (1.6 KB) — 215 evidence rows