Fecal viral filtrates from healthy adults, Ireland
Cross-sectional study of 11 fecal viral filtrate samples from healthy control individuals in Ireland, used to identify gut phages that bind and are internalized by epithelial cells. machine-written summary
11 samples · 11 runs · IE · Age unknown · 2026 · 5.21 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 26 sample values (collection date, country, health condition, health condition detail) |
| ✓ Abstract / description | 18 sample values (health condition, health condition detail) |
| ○ Full text | read; no usable statement or table · PMC13370021 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 11 | 100% | 11 | |||
| health_condition | 11 | 100% | 2 | 9 | ||
| subject_id | 0 | 0% | ||||
| collection_date | 11 | 100% | 11 | |||
| health_condition_detail | 11 | 100% | 2 | 9 |
- Prevalent gut phages encode modular adhesins mediating epithelial binding and endoplasmic reticulum trafficking. 2026 PMID 42236487 PMC13370021 own_data
- Prevalent Gut Phages Encode Modular Adhesins Mediating Epithelial Binding and Endoplasmic Reticulum Trafficking 2026 own_data
Archive description
Bacteriophages are crucial components of the human microbiome and hold promise as therapeutic agents. Yet, their physical interactions with mammalian cells remain poorly understood. Here, we developed a high-throughput platform to identify phages that adhere to epithelial layers and the proteins that mediate this interaction. The identified phages encode immunoglobulin (Ig)-like domain-containing proteins that, when displayed on a non-adherent phage, confer epithelial binding and internalization in vitro, and increased phage retention in the mouse gut in vivo. Phages encoding these adhesins are among the most abundant and prevalent human gut phages, including crAss-like phages and a distinct cluster of uncharacterized myophages. Domain sequence variation alters epithelial interaction profiles, and internalized phages traffic to the endoplasmic reticulum through the Golgi apparatus, suggesting access to non-degradative internalization pathways. These findings reveal widespread phage-human interactions in the human virome, with potential impacts on health and implications for next-generation phage therapeutics.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.70. Assay shotgun_dna.
- host study.title · “human derived fecal viral filtrates”
- body site run.scientific_name · “human viral metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA121053044 | collection_date | 2021-12-05 | R1 | 0.90 | biosample.attribute:collection_date | 2021-12-05 |
| SAMEA121053044 | country | IE | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Ireland |
| SAMEA121053045 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:description | Filtrate of 10 healthy individuals |
| SAMEA121053044 | health_condition | healthy_control | R4 | 0.35 | study.title | human derived fecal viral filtrates |
| SAMEA121053045 | health_condition_detail | healthy | R1 | 0.70 | sample.name_rule:description | Filtrate of 10 healthy individuals |
| SAMEA121053044 | health_condition_detail | Human-derived fecal samples; no disease stated | R4 | 0.35 | study.title | human derived fecal viral filtrates |
Sequencing
11 runs over 11 samples · mean 5.04 Gbp per run (median 5.21 Gbp, total 55.43 Gbp; 11 runs with a base count) · layout PAIRED 11 · platform ILLUMINA 11 · models Illumina HiSeq 2500 (11) · 0% of runs with a Sandpiper profile · first public 2026-06-06
Authors (17)
Apjok G first · Sári T · Méhi O · Asbóth A · Barna L · Sala D · Gróf I · Vásárhelyi BM · Juhász S · Pál C · Horváth P · Migh E · Schneider G · Hill C · Deli M · Shkoporov A · Kintses B last
Downloads
PRJEB107177.csv.gz (1.2 KB) · parquet (69.4 KB) — all 11 samples, every field with route and confidence · PRJEB107177_determinations.csv.gz (979 B) — 44 evidence rows