Resistant dextrin fiber trial in healthy adults, France
359 fecal samples from healthy male adults in France with high or low habitual fiber intake, in a randomized, double-blind, placebo-controlled trial of resistant dextrin supplementation versus maltodextrin placebo. machine-written summary
359 samples · 359 runs · FR · Adult · 2026 · 1.24 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,436 sample values (collection date, country, health condition, health condition detail) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 718 sample values (antibiotic exposure, sex) · PMC13232062 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Prebiotic / dietary fibre supplement design randomized_controlled_trial · population healthy_control · 15 g/day resistant dextrin fiber vs maltodextrin placebo, 4 weeks
“randomized, double-blind, placebo-controlled trial” — abstract:42245546 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 359 | 100% | ||||
| country | 359 | 100% | 359 | |||
| health_condition | 359 | 100% | 359 | |||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 359 | 100% | 359 | |||
| collection_date | 359 | 100% | 359 | |||
| health_condition_detail | 359 | 100% | 359 | |||
| sex | 359 | 100% | 359 |
- Resistant dextrin promotes beneficial fecal bacteria in high and low fiber diet populations: a randomized, double-blinded, controlled pilot study. 2026 PMID 42245546 PMC13232062 own_data
Archive description
Background and objectives: The average intake of dietary fibers known to beneficially modulate the gut microbiota is below recommendations in high-income countries. This study aimed to evaluate the gut effects of resistant dextrin in healthy male adults with normal weight, consuming high (≥25 g/day HF) or low (≤15 g/day LF) levels of fiber as part of their usual diet. Methods: In this randomized, double-blind, placebo-controlled trial, participants received either 15 g/day of resistant dextrin (NUTRIOSE® soluble fiber) or a placebo (maltodextrin) for 4 weeks. Gut microbiota composition, and especially the relative abundance of the Parabacteroides genus, gut microbiota function, fecal parameters (pH, short chain fatty acids [SCFAs] and secretory IgA), and stool frequency and consistency, were assessed. Results: Overall, 124 subjects were recruited, 62 in each treatment arm 57 in HF 67 in LF age: 36.2 ± 11.6 years. The mean relative abundance of Parabacteroides at baseline was similar in the LF (1.5%) and HF (1.3%) subgroups. It increased with the active supplementation and remained stable with the placebo, both in the entire population (5.5% vs 1.4% p<0.0001) and in the subgroups of dietary fiber intake (HF: 5.5% vs. 1.5% LF: 5.5% vs. 1.3% p<0.0001), then returned to baseline levels two weeks later. Among Parabacteroides, P. distasonis showed the highest abundance in the active arm as compared to placebo (2.6% vs. 0.5% p<0.0001). The Bacillota phylum was less abundant at the end of active supplementation compared to placebo (55.4% vs 59.0% p=0.0545). Conversely, several species from the Clostridium genus were more abundant. From a functional perspective, resistant dextrin intake tended to increase bacterial genes involved in α- and β-glucosidase activities, and to decrease those involved in propionate production, especially in the HF subgroup. No treatment effect was found on pH, SCFAs, IgA, stool consistency and frequency. Conclusions: The tested resistant dextrin was effective in modulating the gut microbiota after four weeks of supplementation in healthy male volunteers, favoring the Parabacteroides genus and several related species (especially P. distasonis). The treatment effect was observed in both subgroups of dietary fiber intake, and was even more pronounced in the high-intake subgroup
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.85. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
- life stage study.description · “age: 36.2 ± 11.6 years”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA121345179 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | treatment ended less than 4 weeks before inclusion |
| SAMEA121345179 | collection_date | 2024/2025 | R1 | 0.90 | biosample.attribute:collection_date | 2024/2025 |
| SAMEA121345179 | country | FR | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | France |
| SAMEA121345179 | health_condition | healthy_control | R1 | 0.90 | biosample_attr | healthy |
| SAMEA121345179 | health_condition_detail | healthy | R1 | 0.90 | sample.attr.host_disease_status | healthy |
| SAMEA121345179 | sex | male | R3 | 0.70 | paper.fulltext.methods | healthy male adult volunteers with a low or high level |
Sequencing
359 runs over 359 samples · mean 1.47 Gbp per run (median 1.24 Gbp, total 526.58 Gbp; 359 runs with a base count) · layout PAIRED 359 · platform DNBSEQ 359 · models DNBSEQ-G400 (359) · 0% of runs with a Sandpiper profile · first public 2026-02-13
Authors (6)
Perreau C first · Tomassi D · Capronnier O · Carton T · Thabuis C · Guérin-Deremaux L last
Downloads
PRJEB108118.csv.gz (8.2 KB) · parquet (82.3 KB) — all 359 samples, every field with route and confidence · PRJEB108118_determinations.csv.gz (9.0 KB) — 2,154 evidence rows