Metagenomics after vancomycin, 2'-FL vs placebo RCT
54 stool samples from adults in the Netherlands, all treated with vancomycin for seven days then randomised to a 2'-FL prebiotic or placebo intervention group; intervention study design. machine-written summary
54 samples · 54 runs · NL · Adult · 2026 · 1.26 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 594 sample values (age, bmi, collection date, country, intervention, latitude, location region, longitude) |
| ✓ Abstract / description | 54 sample values (antibiotic exposure) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Antibiotic given as the study intervention (incl. eradication therapy Prebiotic / dietary fibre supplement design randomized_controlled_trial · population healthy_control · Vancomycin 7 days, then randomised to 2'-FL prebiotic vs placebo
“treated with vancomycin for seven days, and subsequently randomised” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
18 of 18 people sampled more than once (54 samples; median 3, up to 3 per person).
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 54 | 100% | ||||
| country | 54 | 100% | 54 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 54 | 100% | 54 | |||
| age_at_collection_days | 54 | 100% | 54 | |||
| antibiotic_exposure | 54 | 100% | 54 | |||
| bmi | 54 | 100% | 54 | |||
| collection_date | 54 | 100% | 54 | |||
| detailed_location | 54 | 100% | ||||
| intervention | 54 | 100% | 54 | |||
| latitude | 54 | 100% | 54 | |||
| location_region | 54 | 100% | 54 | |||
| longitude | 54 | 100% | 54 | |||
| sex | 54 | 100% | 54 | |||
| timepoint_label | 54 | 100% | 54 |
Archive description
Stool samples from participants in the CARMA study in all which participants were treated with vancomycin for seven days, and subsequently randomised to 2'-FL prebiotic or placebo intervention groups.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “CARMA: Human gut long read metagenomics”
- body site study.description · “Stool samples from participants”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA121524642 | age_at_collection_days | 16069.0 | R1 | 0.85 | sample.attr.host_age | 44 |
| SAMEA121524642 | antibiotic_exposure | yes | R4 | 0.50 | study.description | all which participants were treated with vancomycin for seven days |
| SAMEA121524642 | bmi | 31.07 | R1 | 0.90 | sample.attr.host_body_mass_index | 31.0650887573965 |
| SAMEA121524642 | collection_date | 2020 | R1 | 0.90 | biosample.attribute:collection_date | 2020 |
| SAMEA121524642 | country | NL | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Netherlands |
| SAMEA121524642 | intervention | placebo | R1 | 0.85 | biosample.attribute:experimental_factor | placebo [OBI_0000825] |
| SAMEA121524642 | latitude | 50.8480 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 50.848 5.688 |
| SAMEA121524642 | location_region | Limburg | R1 | 0.60 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 50.848 5.688 |
| SAMEA121524642 | longitude | 5.6880 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 50.848 5.688 |
| SAMEA121524642 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
| SAMEA121524642 | subject_id | CAR-001 | R1 | 0.85 | sample.attr.host_subject_id | CAR-001 |
| SAMEA121524642 | timepoint_label | CID1 | R1 | 0.85 | sample.attr.time_point | CID1 |
Sequencing
54 runs over 54 samples · mean 1.33 Gbp per run (median 1.26 Gbp, total 71.78 Gbp; 54 runs with a base count) · layout SINGLE 54 · platform OXFORD_NANOPORE 54 · models GridION (54) · 0% of runs with a Sandpiper profile · first public 2026-09-18
Authors (0)
No author record.
Downloads
PRJEB108131.csv.gz (2.4 KB) · parquet (72.6 KB) — all 54 samples, every field with route and confidence · PRJEB108131_determinations.csv.gz (6.1 KB) — 648 evidence rows