Chronic functional constipation vs healthy controls, China
78 fecal shotgun metagenome samples from China, comparing chronic functional constipation patients and healthy controls in a case-control study of bacterial, fungal, and viral community differences. machine-written summary
78 samples · 78 runs · CN · Age unknown · 2026 · 1.99 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 78 sample values (country) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 156 sample values (antibiotic exposure, location site) · PMC13050957 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 78 | 100% | 78 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 78 | 100% | 78 | |||
| detailed_location | 78 | 100% | ||||
| location_site | 78 | 100% | 78 |
- Multi-kingdom metagenomic characterization of the gut bacteriome, mycobiome, and virome in chronic functional constipation. 2026 PMID 41947790 PMC13050957 own_data
Archive description
We performed shotgun metagenomic sequencing of fecal samples from 53 chronic functional constipation patients and 48 healthy controls to jointly profile bacterial, fungal, and viral community structure, functional modules, cross-kingdom correlation networks, and the diagnostic performance of multi-kingdom microbial signatures using machine-learning models.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.75. Assay shotgun_dna.
- host run.scientific_name · “human gut metagenome”
- body site study.description · “fecal samples from 53 chronic functional constipation patients”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA121972221 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | use of antibiotics or probiotics within 30 days before sampling |
| SAMEA121972221 | country | CN | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | China |
| SAMEA121972221 | location_site | Second Affiliated Hospital of Dalian Medical University | R3 | 0.70 | paper.fulltext.methods | Second Affiliated Hospital of Dalian Medical University |
Sequencing
78 runs over 78 samples · mean 2.06 Gbp per run (median 1.99 Gbp, total 160.34 Gbp; 78 runs with a base count) · layout SINGLE 78 · platform ILLUMINA 78 · models Illumina HiSeq 2000 (78) · 0% of runs with a Sandpiper profile · first public 2026-03-17 – 2026-03-19
Authors (15)
Sun W first · Li Y · Su J · Mao S · Yang S · Zhu Y · Liu Y · Ma J · You W · Zhang Y · Guo H · Xing G · Li S · Yan Q · Ma X last
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata
Downloads
PRJEB108281.csv.gz (2.6 KB) · parquet (72.3 KB) — all 78 samples, every field with route and confidence · PRJEB108281_determinations.csv.gz (1.4 KB) — 234 evidence rows