Gut microbiome and dietary fibres in young children, Belgium
A longitudinal cohort study of 156 samples from young children in Belgium examining dietary fibre intake in relation to gut microbiome composition and diversity. machine-written summary
156 samples · 156 runs · BE · Infant / toddler · 2026 · 0.60 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 312 sample values (collection date, country) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design observational_with_procedure · Ex vivo fecal fermentation with arabinoxylan, cellulose, pectin, xyloglucan fibres
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 156 | 100% | 156 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 156 | 100% | 156 |
- The impact of dietary fibres on gut microbiome of young children: insights from ex vivo experiments and an observational cohort 2026 own_data
Archive description
During weaning period, the intake of dietary fibres changes and increases dramatically. Given the considerable structural differences, we hypothesized that different fibres may vary in their function. The objective of the study was to explore the impact of specific dietary fibres (arabinoxylan, cellulose, pectin and xyloglucan) on the gut microbiome of children below 3 years. By using ex vivo fecal fermentation experiments, cellular models and cohort data analysis, we assessed how these fibres and their combinations influence infants’ gut microbiota composition, diversity, metabolite production and possible actions on the gut epithelial barrier function. We found that the fermentation with arabinoxylan, xyloglucan and pectin resulted in an increased production of short-chain fatty acids. These fibres also promoted the generation of metabolites with potential health benefits, such as indole-3-lactic acid. By combining the ex vivo fermentation and cellular co-culture experiments, arabinoxylan and xyloglucan were found to be able to maintain gut epithelial barrier integrity upon lipopolysaccharide challenge, and a blend of cellulose, pectin, and xyloglucan dampened different LPS induced cytokines. Moreover, pectin was found supporting the growth of a wide range of microbial species ex vitro and correlated positively with α-diversity in young children in an observational cohort. Our findings provided insights into the potential benefits of diverse fibre intakes during early life. Further studies are needed to understand the mechanisms and the effectiveness of specific fibres on the gut microbiome development in young children.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “dietary fibres on gut microbiome of young”
- body site study.description · “xyloglucan) on the gut microbiome of children”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “their combinations influence infants ’ gut microbiota”
- life stage study.title · “microbiome of young children : insights from”
- life stage study.description · “gut microbiome of children below 3 years.”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA122185917 | collection_date | 2025-12-05 | R1 | 0.85 | biosample.attribute:collection_date | collection_date: 2025-12-05 |
| SAMEA122185917 | country | BE | R1 | 0.90 | biosample_attr | Belgium |
Sequencing
156 runs over 156 samples · mean 0.73 Gbp per run (median 0.60 Gbp, total 113.12 Gbp; 156 runs with a base count) · layout PAIRED 156 · platform ILLUMINA 156 · models NextSeq 2000 (156) · 0% of runs with a Sandpiper profile · first public 2026-04-24
Authors (0)
No author record.
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata
Downloads
PRJEB110410.csv.gz (4.5 KB) · parquet (75.6 KB) — all 156 samples, every field with route and confidence · PRJEB110410_determinations.csv.gz (1.7 KB) — 312 evidence rows