Gut Virome in UC and Crohn's Disease, UK Case-Control
1,122 stool samples from UK patients with ulcerative colitis, Crohn's disease, and household contacts, profiling the gut virome (VLPs) in a case-control design with longitudinal collection. machine-written summary
1,124 samples · 1,124 runs · GB · Age unknown · 2026 · 0.47 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 4,716 sample values (collection date, country, family role, health condition, health condition detail) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolvedhouseholds — not resolved
Schedule stated by the source: “Stated as longitudinal collection to capture temporal variation in gut virome; no specific visit schedule or offsets given”.
IBD patients (130 UC, 86 CD) plus household contacts (220 catalog samples flagged HHC); contact-to-patient household links not deposited.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 1,124 | 100% | 1,124 | |||
| health_condition | 1,124 | 100% | 1,124 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 1,124 | 100% | 1,124 | |||
| health_condition_detail | 1,124 | 100% | 1,124 | |||
| family_role | 220 | 20% | 220 |
Archive description
This study comprises a metagenomic virome dataset generated from stool samples collected from patients with inflammatory bowel disease (IBD) and healthy household controls. A total of 1,123 samples were sequenced, including 412 samples from 130 individuals with ulcerative colitis (UC), 388 samples from 86 individuals with Crohn's disease (CD), 189 samples from household contacts of UC patients, and 134 samples from household contacts of CD patients. Samples were collected longitudinally to capture temporal variation in the gut virome across differing disease states and inflammatory activity, as assessed by fecal calprotectin levels. Virus-like particles (VLPs) were isolated from stool and subjected to random amplification using the Round AB protocol prior to Illumina sequencing, enabling characterization of the enteric DNA and RNA virome.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.78. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.description · “stool samples collected from patients”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA122138751 | collection_date | 2016-01-27 | R1 | 0.90 | biosample.attribute:collection_date | 2016-01-27 |
| SAMEA122138751 | country | GB | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | United Kingdom |
| SAMEA122138752 | family_role | household_member | R1 | 0.70 | biosample.attribute:description | description: HHC_UC |
| SAMEA122138751 | health_condition | ulcerative_colitis | R1 | 0.85 | biosample.attribute:description | UC |
| SAMEA122138751 | health_condition_detail | UC | R1 | 0.85 | biosample.attribute:description | UC |
Sequencing
1,124 runs over 1,124 samples · mean 0.48 Gbp per run (median 0.47 Gbp, total 534.79 Gbp; 1,124 runs with a base count) · layout PAIRED 1,124 · platform ILLUMINA 1,124 · models Illumina MiSeq (1,124) · 0% of runs with a Sandpiper profile · first public 2026-04-12
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, subject_id. Share metadata
Downloads
PRJEB110648.csv.gz (25.7 KB) · parquet (114.4 KB) — all 1,124 samples, every field with route and confidence · PRJEB110648_determinations.csv.gz (35.1 KB) — 4,716 evidence rows