Gut microbiome and frailty in older Swedish women
Cross-sectional study of 2,398 gut metagenome samples from Swedish women aged 75–80 (SUPERB cohort), examining associations between gut microbiota and frailty severity, assessed via a Frailty Mortality Index. machine-written summary
2,398 samples · 2,398 runs · SE · Adult · 2026 · 7.48 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 11,990 sample values (collection date, country, latitude, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 7,194 sample values (antibiotic exposure, location locality, sex) · PMC13346421 |
| ✓ Supplementary tables | 2,081 sample values (health condition detail) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 2,398 | 100% | ||||
| country | 2,398 | 100% | 2,398 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 2,398 | 100% | 2,398 | |||
| collection_date | 2,398 | 100% | 2,398 | |||
| detailed_location | 2,398 | 100% | ||||
| latitude | 2,398 | 100% | 2,398 | |||
| location_locality | 2,398 | 100% | 2,398 | |||
| location_region | 2,398 | 100% | 2,398 | |||
| longitude | 2,398 | 100% | 2,398 | |||
| sex | 2,398 | 100% | 2,398 | |||
| health_condition_detail | 2,081 | 87% | 2,081 |
- Gut microbiota associates with frailty in older women. 2026 PMID 42420265 PMC13346421 own_data
Archive description
Frailty is a multifactorial geriatric condition linked to increased mortality and adverse health outcomes and is associated with gut microbiome features that differ from those observed in healthy ageing. We analyse gut metagenomic profiles in relation to estimated frailty severity and frailty-related clinical outcomes assessed with an internally developed and validated Frailty Mortality Index (FMI) in the SUPERB cohort, comprising 2,081 Swedish women aged 75–80 years. The FMI is a composite measure that integrates functional, physiological and psychological dimensions associated with frailty and mortality risk, and shows stronger associations with mortality compared to the Charlson Comorbidity Index in the SUPERB cohort. The FMI is inversely associated with microbial diversity, gene richness, and predicted functional capacity, which are linked to physical function, mortality and fall-related injuries. A total of 404 bacterial species are significantly associated with FMI, and most show concordant associations in a Chinese cohort of 1,448 older adults. Here we show microbial signatures linked to frailty and mortality across different continents.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_unknown_no_evidence”
- body site study.title · “Gut microbiota associates with”
- body site study.description · “is associated with gut microbiome features that”
- life stage study.title · “frailty in older women”
- life stage study.description · “comprising 2,081 Swedish women aged 75–80 years.”
- life stage study.description · “is a multifactorial geriatric condition linked to”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA122051526 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | any prescription for oral antibiotics in the past 90 days |
| SAMEA122051526 | collection_date | 2016 | R1 | 0.90 | biosample.attribute:collection_date | 2016 |
| SAMEA122051526 | country | SE | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Sweden |
| SAMEA122051526 | health_condition_detail | Moderate frailty | R2 | 0.85 | paper.supp.41467_2026_75176_MOESM6_ESM.xlsx[Source Data Fig. 2a!Group] | Moderate frailty |
| SAMEA122051526 | latitude | 57.7060 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 57.706 11.954 |
| SAMEA122051526 | location_locality | Gothenburg | R3 | 0.70 | paper.fulltext.methods | conducted in the Gothenburg area, Sweden |
| SAMEA122051526 | location_region | Vaestra Goetaland | R1 | 0.60 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 57.706 11.954 |
| SAMEA122051526 | longitude | 11.9540 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 57.706 11.954 |
| SAMEA122051526 | sex | female | R3 | 0.70 | paper.fulltext.abstract | 2,081 Swedish women aged 75–80 years |
Sequencing
2,398 runs over 2,398 samples · mean 7.62 Gbp per run (median 7.48 Gbp, total 18,270.47 Gbp; 2,398 runs with a base count) · layout PAIRED 2,398 · platform ILLUMINA 2,398 · models Illumina NovaSeq 6000 (2,398) · 0% of runs with a Sandpiper profile · first public 2026-06-03
Authors (13)
Vilar Geraldi M first · Dwibedi C · Jaiswal R · Gregori G · Zhou X · Lv B · Zheng Y · Wang X · Wu H · Axelsson KF · Bäckhed F · Tremaroli V · Lorentzon M last
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJEB110772.csv.gz (54.9 KB) · parquet (157.6 KB) — all 2,398 samples, every field with route and confidence · PRJEB110772_determinations.csv.gz (106.1 KB) — 21,265 evidence rows