Other administered intervention (see intervention_detail)designrandomized_controlled_trial · Maternal vaginal/gut microbial transplant at birth vs placebo
“randomly selected for intervention (microbial transplant from mother) or placebo” — bioproject.description (study level; per-sample arms are in the intervention column below)
Samples at a glance
1 country
Age
infant1,257
adult124
unknown60
Condition
intervention_cohort705
Country
SE1,441
Body site
excluded714
primary543
linked184
Collected 2008–2024
Sequencing depth per sample · this project all projects
Sampling design and relatedness
longitudinal — not resolvedmother–infant
129 of 206 people sampled more than once (466 samples; median 4, up to 5 per person).
Schedule stated by the source: “Samples taken at birth, then at one month, six months, 12 months and 24 months” (time origin: birth); stated follow-up 2.0 y.
226 dyad ids (host subject id) shared by maternal vaginal and child faecal samples; 140 with both; C-section infants randomised to maternal microbial transfer · 193 families with 1,034 sampled people (140 with a parent and a child).
39 × mother + child + unknown×5
27 × child + unknown
26 × mother + child + unknown×4
20 × mother + child + unknown×3
19 × mother + child + unknown×6
14 × mother + child + unknown
12 × mother + child + unknown×7
7 × child + unknown×3
motherchildmember · circles are people (pale = no sequenced sample), arrows run donor → recipient and parent → child, curved lines join twins, partners and siblings, squares are shared settings or families without recorded roles. Shown: 24 of 193 families (one per family structure, then more). 206 people in the project overall.
The purpose of this study is to establish whether children delivered by caesarean section who are immediately rubbed with the mother’s vaginal and gut microflora (intervention group) then develop a bacterial flora similar to that of vaginally delivered babies. We will also be examining whether this treatment can reduce the risk of developing allergies. Children born to healthy women by planned caesarean section will be randomly selected for intervention (microbial transplant from mother) or placebo, with children delivered virginally included as a control group. When the child is born, samples of bacterial flora will be taken from the skin (mother and child), breastmilk and the child’s faeces. The same samples will be taken at one month, six months, 12 months and 24 months.
How this project entered the registry
Classified as human gut / stool / skin / vaginal / urogenital / human milk shotgun DNA metagenome of infant / toddler and neonate and child and adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
body sitestudy.description · “mother’s vaginal and gut microflora (intervention group)”
body siteexternal_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
body sitestudy.description · “taken from the skin (mother and child),”
body sitestudy.description · “with the mother’s vaginal and gut microflora”
body sitestudy.description · “(mother and child), breastmilk and the child’s”
life stageexternal_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
life stagestudy.description · “of vaginally delivered babies . We will”
life stagestudy.title · “of Microbiota in Newborns”
life stagestudy.description · “to establish whether children delivered by caesarean”
life stagestudy.description · “born to healthy women by planned caesarean”
Evidence examples (one per field × route)
sample
field
value
route
conf.
source
quote
SAMEA122175587
age_at_collection_days
11323.0
R1
0.85
biosample.attribute:host age
31
SAMEA122174776
collection_date
2020
R1
0.85
biosample.attribute:collection date
2020
SAMEA122174776
country
SE
R1
0.90
biosample_attr
Sweden
SAMEA122174776
family_id
U032
R1
0.60
biosample.attribute:host subject id
host subject id: U032; host body site: Saliva
SAMEA122174777
family_role
child
R1
0.60
biosample.attribute:host body site
host body site: Faeces
SAMEA122174776
health_condition
intervention_cohort
R1
0.80
biosample.attribute:host_disease_status
host_disease_status: C-Section Placebo
SAMEA122174776
health_condition_detail
C-Section Placebo
R1
0.90
biosample.attribute:host_disease_status
host_disease_status: C-Section Placebo
SAMEA122174776
intervention
placebo
R1
0.85
biosample.attribute:host disease status
C-Section Placebo
SAMEA122174777
subject_id
LN023_child
R2
0.80
archive
Sequencing
1,441 runs over 1,441 samples · mean 16.46 Gbp per run (median 17.53 Gbp, total 23,723.50 Gbp; 1,441 runs with a base count) · layout PAIRED 1,441 · platform DNBSEQ 1,441 · models DNBSEQ-T7 (863), DNBSEQ-G400 (578) · 0% of runs with a Sandpiper profile · first public 2026-04-17 – 2026-04-18