POINTER trial - diet/exercise intervention, US older adults
768 gut metagenome samples (725 USA, 43 missing location) from a randomized clinical trial testing diet and exercise lifestyle interventions to reduce cognitive decline risk in older adults at increased risk of dementia. machine-written summary
768 samples · 768 runs · US · Adult · 2026 · 1.47 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 2,900 sample values (collection date, country, latitude, longitude) |
| ✓ Abstract / description | 43 sample values (country) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Controlled / prescribed diet or feeding regimen Exercise / physical-training programme design randomized_controlled_trial · population neurological_psychiatric · 2-year lifestyle intervention: structured diet and exercise, varying intensity
“randomized 2-year clinical trial of two lifestyle interventions” — bioproject.description (study level; per-sample arms are in the intervention column below)
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 768 | 100% | 725 | 43 | ||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 725 | 94% | 725 | |||
| latitude | 725 | 94% | 725 | |||
| longitude | 725 | 94% | 725 |
Archive description
POINTER - U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk Phase III, multicenter, randomized 2-year clinical trial of two lifestyle interventions varying in intensity and format, in 2000 older adults at increased risk of cognitive decline and dementia in the United States
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.description · “in 2000 older adults at increased risk”
- life stage study.description · “format, in 2000 older adults at increased risk”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA122900765 | collection_date | 2021-12-17 | R1 | 0.90 | biosample.attribute:collection_date | 2021-12-17 |
| SAMEA122900765 | country | US | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | USA |
| SAMEA122901075 | country | US | R4 | 0.50 | study.description | in the United States |
| SAMEA122900765 | latitude | 35.9700 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 35.97 -78.9 |
| SAMEA122900765 | longitude | -78.9000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 35.97 -78.9 |
Sequencing
768 runs over 768 samples · mean 1.86 Gbp per run (median 1.47 Gbp, total 1,431.44 Gbp; 768 runs with a base count) · layout PAIRED 768 · platform ILLUMINA 768 · models Illumina NovaSeq 6000 (768) · 0% of runs with a Sandpiper profile · first public 2026-06-30
Authors (0)
No author record.
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata
Downloads
PRJEB115008.csv.gz (18.0 KB) · parquet (98.7 KB) — all 768 samples, every field with route and confidence · PRJEB115008_determinations.csv.gz (17.0 KB) — 2,943 evidence rows