Gut microbiome and DHA supplementation in APOE ε4 carriers, USA
189 samples from a double-blind, placebo-controlled, randomized trial in US adults testing whether APOE ε4 allele status affects brain DHA delivery, with 2g/day DHA or placebo plus vitamin B over 2 years. machine-written summary
189 samples · 189 runs · US · Adult · 2026 · 3.58 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 620 sample values (collection date, country, latitude, location region, longitude) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-microbial dietary supplement (vitamins design randomized_controlled_trial · population healthy_control · 2g DHA algal oil + vitamin B daily vs placebo, 2 years
“2 grams of DHA or placebo” — bioproject.description (study level; per-sample arms are in the intervention column below)
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 189 | 100% | ||||
| country | 124 | 66% | 124 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 124 | 66% | 124 | |||
| detailed_location | 124 | 66% | ||||
| latitude | 124 | 66% | 124 | |||
| location_region | 124 | 66% | 124 | |||
| longitude | 124 | 66% | 124 |
Archive description
PreventE4 is a double-blind single-site placebo-controlled parallel group randomized trial with 1:1 allocation to identify whether carrying the APOE ε4 allele is associated with reduced delivery of DHA to the brain. A total of 2 grams of DHA or placebo are consumed a day along with 1 supplement of vitamin B for a 2-year intervention period. The DHA intervention capsules contain algal-derived triglyceride DHA-S. The placebo is composed of 50% corn oil and 50% soy oil.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “effect of the Gut Microbiome on the”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA122904418 | collection_date | 2025 | R1 | 0.90 | biosample.attribute:collection_date | 2025 |
| SAMEA122904418 | country | US | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | USA |
| SAMEA122904418 | latitude | 34.0500 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 34.05 -118.25 |
| SAMEA122904418 | location_region | California | R1 | 0.60 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 34.05 -118.25 |
| SAMEA122904418 | longitude | -118.2500 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 34.05 -118.25 |
Sequencing
189 runs over 189 samples · mean 3.04 Gbp per run (median 3.58 Gbp, total 574.46 Gbp; 189 runs with a base count) · layout PAIRED 189 · platform ILLUMINA 189 · models Illumina NovaSeq X (189) · 0% of runs with a Sandpiper profile · first public 2026-06-30
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJEB115011.csv.gz (4.9 KB) · parquet (76.3 KB) — all 189 samples, every field with route and confidence · PRJEB115011_determinations.csv.gz (3.7 KB) — 620 evidence rows