FMT plus exclusion diet for Crohn's disease, India RCT
99 adult samples from India with Crohn's disease, studied in a randomized sham-controlled trial of fecal microbiota transplantation combined with the Crohn's Disease Exclusion Diet versus diet alone. machine-written summary
99 samples · 99 runs · IN · Adult · 2026 · 7.40 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 423 sample values (collection date, country, intervention, subject id, timepoint) |
| ✓ Abstract / description | 198 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Controlled / prescribed diet or feeding regimen Faecal microbiota transplantation design randomized_controlled_trial · population crohns_disease · FMT plus CDED vs sham FMT plus CDED, 52-week trial in Crohn's disease
“combining Fecal Microbiota Transplantation (FMT) with the Crohn's Disease Exclusion Diet” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinalFMT donor → recipient — not resolved
22 of 22 people sampled more than once (75 samples; median 4, up to 4 per person) · follow-up median 12 mo (max 12 mo) · median interval between samples 4 mo (time from timepoint numbers, unit from the stated sampling schedule). Schedule stated by the source: “stool at 0, 12, 28 and 52 weeks” (time origin: intervention start); stated follow-up 12 mo.
Each row is one person (22 shown); dots are samples at days since that person's first sample.
FMT+CDED vs sham trial; 24 samples titled D<n>-0-week-CDFMT<n> appear to be donor stool paired to 12 recipients — pairing not committed (replicate split).
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 99 | 100% | ||||
| country | 99 | 100% | 99 | |||
| health_condition | 99 | 100% | 99 | |||
| subject_id | 75 | 76% | 75 | |||
| collection_date | 99 | 100% | 99 | |||
| health_condition_detail | 99 | 100% | 99 | |||
| intervention | 75 | 76% | 75 | |||
| timepoint_label | 75 | 76% | 75 |
Archive description
This clinical trial investigated whether combining Fecal Microbiota Transplantation (FMT) with the Crohn's Disease Exclusion Diet (CDED) is more effective than CDED alone (sham + CDED) for treating mild-to-moderate Crohn's disease. The FMT + CDED combination showed significant benefits: it dramatically reduced long-term treatment failure (5.9% vs 46.2%), improved combined clinical and endoscopic responses, and successfully promoted the lasting engraftment of beneficial gut bacteria.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “microbiome restructuring following fecal microbiota transplantation plus”
- body site study.description · “investigated whether combining Fecal Microbiota Transplantation (FMT)”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA122919184 | collection_date | 2023 | R1 | 0.90 | biosample.attribute:collection_date | 2023 |
| SAMEA122919184 | country | IN | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | India |
| SAMEA122919184 | health_condition | crohns_disease | R4 | 0.50 | study.description | Crohn's disease |
| SAMEA122919184 | health_condition_detail | mild-to-moderate Crohn's disease | R4 | 0.50 | study.description | mild-to-moderate Crohn's disease |
| SAMEA122919184 | intervention | fmt | R1 | 0.70 | sample.name_rule:sample_title | CDFMT1-A-0-week |
| SAMEA122919184 | subject_id | CDFMT1 | R1 | 0.70 | sample.name_rule:sample_title | CDFMT1-A-0-week |
| SAMEA122919184 | timepoint_label | 0 | R1 | 0.70 | sample.name_rule:sample_title | CDFMT1-A-0-week |
Sequencing
99 runs over 99 samples · mean 8.02 Gbp per run (median 7.40 Gbp, total 793.90 Gbp; 99 runs with a base count) · layout PAIRED 99 · platform ILLUMINA 99 · models Illumina MiSeq (99) · 0% of runs with a Sandpiper profile · first public 2026-07-02
Authors (0)
No author record.
Downloads
PRJEB115184.csv.gz (3.4 KB) · parquet (73.7 KB) — all 99 samples, every field with route and confidence · PRJEB115184_determinations.csv.gz (5.2 KB) — 621 evidence rows