Microbiota in obesity: Chinese young adults, case-control
Metagenome-wide association study of 257 fecal samples from 95 obese and 105 normal-weight Chinese young adults, plus 23 obese patients after weight loss, identifying microbial species linked to obesity and treatment response. machine-written summary
257 samples · 257 runs · CN · Adult · 2016 · 5.09 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 706 sample values (collection date, country, subject id, timepoint) |
| ✓ Abstract / description | 52 sample values (health condition detail) |
| ○ Full text | read; no usable statement or table · PMC10059959, PMC11169845, PMC11444864, PMC11958714, PMC12677068, PMC13097810 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| ✓ External resources | 410 sample values (health condition, health condition detail) · from GMrepo v3 |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
23 of 112 people sampled more than once (63 samples; median 3, up to 3 per person).
Genera, mean relative abundance over 233 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 257 | 100% | ||||
| country | 257 | 100% | 257 | |||
| health_condition | 205 | 80% | 205 | |||
| subject_id | 152 | 59% | 152 | |||
| collection_date | 257 | 100% | 257 | |||
| health_condition_detail | 257 | 100% | 205 | 52 | ||
| timepoint_label | 40 | 16% | 40 |
- Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human Gut Bacteroides. 2020 PMID 32265336 PMC7157763 unsure
- Human Gut Faecalibacterium prausnitzii Deploys a Highly Efficient Conserved System To Cross-Feed on β-Mannan-Derived Oligosaccharides. 2021 PMID 34061597 PMC8262883 unsure
- Metagenomic analysis revealed the potential role of gut microbiome in gout. 2021 PMID 34373464 PMC8352958 unsure
- Diverse events have transferred genes for edible seaweed digestion from marine to human gut bacteria. 2022 PMID 35240043 PMC9096808 unsure
- Machine learning framework for gut microbiome biomarkers discovery and modulation analysis in large-scale obese population. 2022 PMID 36564713 PMC9789565 unsure
11 more
- 2 Hydroxybutyric Acid-Producing Bacteria in Gut Microbiome and Fusobacterium nucleatum Regulates 2 Hydroxybutyric Acid Level In Vivo. 2023 PMID 36984891 PMC10059959
- Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift. 2024 PMID 38265338 PMC10810176
- Christensenella strain resources, genomic/metabolomic profiling, and association with host at species level. 2024 PMID 38722028 PMC11085954
- Genomic and functional diversity of the human-derived isolates of <i>Faecalibacterium</i>. 2024 PMID 38873165 PMC11169845
- The molecular basis of cereal mixed-linkage β-glucan utilization by the human gut bacterium Segatella copri. 2024 PMID 39122003 PMC11418011
- Lactobacillus acidophilus CICC 6075 attenuates high-fat diet-induced obesity by improving gut microbiota composition and histidine biosynthesis. 2024 PMID 39364122 PMC11444864
- MAGs-based genomic comparison of gut significantly enriched microbes in obese individuals pre- and post-bariatric surgery across diverse locations. 2025 PMID 40171165 PMC11958714
- Multi-omics integration reveals functional signatures of gut microbiome in atherosclerosis. 2025 PMID 40785047 PMC12341049
- The gut methanotroph Methylocystis intestini modulates intestinal peristalsis and fat metabolism via reducing methane levels. 2025 PMID 41331251 PMC12764784
- <i>Christensenella intestinihominis</i> MNO-863 improve obesity and related metabolic disorders via SCFAs-induced GLP-1 hormone secretion. 2025 PMID 41356823 PMC12677068
- Therapeutic modulation of the gut-liver axis with faecalibacterium prausnitzii in metabolic dysfunction-associated steatohepatitis. 2026 PMID 41820829 PMC13097810
Archive description
Obesity has become a global epidemic as a high risk factor for type 2 diabetes, cardiovascular diseases and cancer. Besides human genetics, our gut microbiome is another contributor to human obesity. Here we perform metagenome-wide association studies (MGWAS) on fecal samples from a case-control cohort including 95 Chinese young adults with obesity and 105 normal-weight controls, and 23 obese patients after weight-loss treatment. We discover and validate microbial species deregulated in obesity, and show the changes of gut microbial composition after weight-loss treatment.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_unknown_no_evidence”
- body site study.title · “Gut microbial dysbiosis in”
- body site study.description · “human genetics, our gut microbiome is another”
- life stage study.title · “dysbiosis in young adults with obesity”
- life stage study.description · “95 Chinese young adults with obesity and”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA3708458 | collection_date | 2014 | R1 | 0.90 | biosample.attribute:collection_date | 2014 |
| SAMEA3708458 | country | CN | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | China |
| SAMEA3708458 | health_condition | obesity | R2 | 0.75 | external.gmrepo source | phenotype: Obesity |
| SAMEA3708458 | health_condition_detail | Obesity | R2 | 0.75 | external.gmrepo source | phenotype: Obesity |
| SAMEA3708467 | health_condition_detail | obesity and normal-weight controls; post-weight-loss treatment subgroup | R4 | 0.50 | study.description | case-control cohort including 95 Chinese young adults with obesity and 105 normal-weight |
| SAMEA3708458 | subject_id | DB44 | R1 | 0.70 | sample.name_rule:common name | DB44 |
| SAMEA3708536 | timepoint_label | S1 | R1 | 0.70 | sample.name_rule:common name | DB-S1-68 |
Sequencing
257 runs over 257 samples · mean 5.20 Gbp per run (median 5.09 Gbp, total 1,335.82 Gbp; 257 runs with a base count) · layout PAIRED 257 · platform ILLUMINA 257 · models Illumina HiSeq 2500 (257) · 91% of runs with a Sandpiper profile · first public 2016-05-31
Authors (32)
Qin F first · Li J · Mao T · Feng S · Lai M last · Li W first · Lin X · Liang H · Wu Z · Wang M · Sun J · Li X · He W · Gao X · Hu T · Xiao L · Zou Y last · Zhang S first · Yang S · Zhuang Y · Yang D · Gu X · Wang Y · Wang Z · Chen R · Yan F last · Shi H first · Chen H first · Su W · Liu Y · Li S · Zhou X last
Downloads
PRJEB12123.csv.gz (7.3 KB) · parquet (79.7 KB) — all 257 samples, every field with route and confidence · PRJEB12123_determinations.csv.gz (10.0 KB) — 1,168 evidence rows