Gut microbiome in NAFLD: bariatric patients, Italy/Spain
73 faecal metagenome samples from adult bariatric surgery patients with liver disease (NAFLD) in Italy (41) and Spain (32), studied using a case-control design. machine-written summary
73 samples · 73 runs · IT, ES · Adult · 2018 · 3.87 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 730 sample values (age, bmi, collection date, country, health condition, health condition detail, latitude, location region) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 73 sample values (subject id) · PMC10772641, PMC11444864, PMC11602751, PMC12764784, PMC12853991, PMC13097810, PMC13170203, PMC13275893, PMC8106161, PMC8548776 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 68 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 73 | 100% | ||||
| country | 73 | 100% | 73 | |||
| health_condition | 73 | 100% | 73 | |||
| subject_id | 73 | 100% | 73 | |||
| age_at_collection_days | 73 | 100% | 73 | |||
| bmi | 73 | 100% | 73 | |||
| collection_date | 73 | 100% | 73 | |||
| detailed_location | 73 | 100% | ||||
| health_condition_detail | 73 | 100% | 73 | |||
| latitude | 73 | 100% | 73 | |||
| location_region | 73 | 100% | 73 | |||
| longitude | 73 | 100% | 73 | |||
| sex | 73 | 100% | 73 |
- Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome. 2021 PMID 33962692 PMC8106161 own_data
- Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity. 2023 PMID 38118419 PMC10772641 own_data
- The gut microbiota-derived metabolite indole-3-propionic acid enhances leptin sensitivity by targeting STAT3 against diet-induced obesity. 2024 PMID 39606796 PMC11602751 own_data
- Disentangling the Progression of Non-alcoholic Fatty Liver Disease in the Human Gut Microbiota. 2021 PMID 34721326 PMC8548776 unsure
- Lactobacillus acidophilus CICC 6075 attenuates high-fat diet-induced obesity by improving gut microbiota composition and histidine biosynthesis. 2024 PMID 39364122 PMC11444864 unsure
5 more
- The gut methanotroph Methylocystis intestini modulates intestinal peristalsis and fat metabolism via reducing methane levels. 2025 PMID 41331251 PMC12764784
- Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes. 2025 PMID 41413769 PMC12853991
- Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum. 2026 PMID 41816992 PMC13170203
- Therapeutic modulation of the gut-liver axis with faecalibacterium prausnitzii in metabolic dysfunction-associated steatohepatitis. 2026 PMID 41820829 PMC13097810
- Multi-kingdom profiling reveals altered gut phage-bacteria-metabolite interactions in MASLD. 2026 PMID 42000726 PMC13275893
Archive description
As worldwide metabolic disease pandemics rise relentlessly with their concomitant clinical complications such as non-alcoholic fatty liver disease (NAFLD), FLORINASH sought to use an innovative research concept to address the role of the intestinal microbiota in the pathogenesis of NAFLD. Metagenomic data deposited herein are from patients who underwent bariatric surgery, and for whom liver biopsies were available to allow diagnosis of NAFLD.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by opus_adjudicated with confidence 0.75. Assay shotgun_dna.
- host study.description · “patients who underwent bariatric surgery”
- host run.scientific_name · “human gut metagenome”
- body site study.title · “role of the intestinal microflora”
- life stage sample.attr.host_age · “36 (n=70/73)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA4019771 | age_at_collection_days | 16069.0 | R1 | 0.85 | sample.attr.host_age | 44 |
| SAMEA4019771 | bmi | 63.67 | R1 | 0.90 | sample.attr.host_body_mass_index | 63.672 |
| SAMEA4019771 | collection_date | 2010-09-05 | R1 | 0.90 | biosample.attribute:collection_date | 2010-09-05 |
| SAMEA4019771 | country | IT | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Italy |
| SAMEA4019771 | health_condition | liver_disease | R1 | 0.90 | biosample_attr | Non-alcoholic fatty liver disease |
| SAMEA4019771 | health_condition_detail | Non-alcoholic fatty liver disease | R1 | 0.90 | sample.attr.liver_disorder | Non-alcoholic fatty liver disease |
| SAMEA4019771 | latitude | 41.8585 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 41.85846 12.6299 |
| SAMEA4019771 | location_region | Latium | R1 | 0.60 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 41.85846 12.6299 |
| SAMEA4019771 | longitude | 12.6299 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 41.85846 12.6299 |
| SAMEA4019771 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
| SAMEA4019771 | subject_id | SAMEA4019771 | R3 | 0.70 | design.one_sample_per_subject:fulltext | Fecal shotgun sequencing data was generated for n = 73 patients from the discovery cohort |
Sequencing
73 runs over 73 samples · mean 3.97 Gbp per run (median 3.87 Gbp, total 289.48 Gbp; 73 runs with a base count) · layout PAIRED 73 · platform ILLUMINA 73 · models Illumina HiSeq 2500 (48), Illumina HiSeq 2000 (25) · 93% of runs with a Sandpiper profile · first public 2018-03-14
Authors (53)
Wang Z first · Yang S · Liu L · Mao A · Kan H · Yu F · Ma X · Feng L · Zhou T last · Medina-Méndez JM first · Iruzubieta P · Fernández-López R · Crespo J · de la Cruz F last · Rao B first · Jiang J · Zhang R · Zhang D · Zhang C · Li A · Lu H · Zhang H · Zhou L · Guo W · Wen P · Xue J · Pan J · Aji T · Lan Z · Jiang X · Zheng S · Yu Z · Ren Z last · Chen H first · Wang Y · Su W · Liu Y · Li S · Zhou X last · Zhou D · Pu Y · Kim H · Sun Z · Qi W · Jin J · Zhang W · Xia M · Wang C · Hong S · Nguyen LH · Jiao N · Zheng Y · Liu T last
Downloads
PRJEB14215.csv.gz (3.8 KB) · parquet (75.7 KB) — all 73 samples, every field with route and confidence · PRJEB14215_determinations.csv.gz (7.3 KB) — 803 evidence rows