Gut microbiome and gestational diabetes, China, case-control
54 fecal samples from pregnant women (24-28 weeks gestation) in the Born in Guangzhou Cohort Study, China, comparing gut microbiome composition between GDM patients and healthy controls in a case-control design. machine-written summary
54 samples · 54 runs · CN · Adult · 2017 · 6.47 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 108 sample values (collection date, country) |
| ✓ Abstract / description | 54 sample values (location locality) |
| ✓ Full text | 216 sample values (antibiotic exposure, location site, sex, subject id) · PMC11009399, PMC11438002, PMC5597849 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| ✓ External resources | 108 sample values (health condition, health condition detail) · from GMrepo v3 |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 45 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 54 | 100% | ||||
| country | 54 | 100% | 54 | |||
| health_condition | 54 | 100% | 54 | |||
| subject_id | 54 | 100% | 54 | |||
| antibiotic_exposure | 54 | 100% | 54 | |||
| collection_date | 54 | 100% | 54 | |||
| detailed_location | 54 | 100% | ||||
| health_condition_detail | 54 | 100% | 54 | |||
| location_locality | 54 | 100% | 54 | |||
| location_site | 54 | 100% | 54 | |||
| sex | 54 | 100% | 54 |
- Connections between the human gut microbiome and gestational diabetes mellitus. 2017 PMID 28873967 PMC5597849 own_data
- Plasmids in the human gut reveal neutral dispersal and recombination that is overpowered by inflammatory diseases. 2024 PMID 38605009 PMC11009399 unsure
- Clinical significance of the genetically variable landscape of the gut microbiome in patients with gestational diabetes mellitus patients. 2024 PMID 39347390 PMC11438002 unsure
- Plasmid dispersal and recombination across human gut microbiomes is neutral, but overpowered by inflammatory diseases 2023 unsure
Archive description
The gut microbiome could modulate metabolic health and affect insulin resistance, which may play a role in the observed increase in gestational diabetes mellitus (GDM). The aim of this study was to reveal any relationships between gut microbiome composition and GDM in pregnant women at 24-28 weeks gestation. Fecal samples were collected from 124 pregnant women (43 GDM patients and 81 healthy control subjects) during 24-28 weeks gestation, as part of the Born in Guangzhou Cohort Study, China. The gut microbiota profiles were assessed by metagenomic shotgun sequencing to analyze microbial diversity at all taxonomic levels. Maternal GDM status was assessed by 2-hour 75g OGTT between the 24th and 28th week of gestation.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.80. Assay shotgun_dna.
- host run.scientific_name · “human gut metagenome”
- body site study.description · “Fecal samples were collected from 124 pregnant women”
- life stage study.description · “pregnant women at 24-28 weeks gestation”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA37057918 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | not received any antibiotic treatment 1 month before |
| SAMEA37057918 | collection_date | 2015 | R1 | 0.90 | biosample.attribute:collection_date | 2015 |
| SAMEA37057918 | country | CN | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | China |
| SAMEA37057918 | health_condition | pregnancy_postpartum | R2 | 0.75 | external.gmrepo source | phenotype: Diabetes, Gestational |
| SAMEA37057918 | health_condition_detail | Diabetes, Gestational | R2 | 0.75 | external.gmrepo source | phenotype: Diabetes, Gestational |
| SAMEA37057918 | location_locality | Guangzhou | R4 | 0.45 | ena.study_description | Born in Guangzhou Cohort Study |
| SAMEA37057918 | location_site | Guangzhou Women and Children's Medical Center | R3 | 0.70 | paper.fulltext.methods | Guangzhou Women and Children's Medical Center (GWCMC) between 1 August 2012 |
| SAMEA37057918 | sex | female | R3 | 0.70 | paper.fulltext.methods | 124 pregnant women included in the study |
| SAMEA37057918 | subject_id | SAMEA37057918 | R3 | 0.75 | design.one_sample_per_subject:fulltext | we only analyzed 1 stool sample per participant, which was collected in the second trimester of pregnancy |
Sequencing
54 runs over 54 samples · mean 6.65 Gbp per run (median 6.47 Gbp, total 359.12 Gbp; 54 runs with a base count) · layout PAIRED 54 · platform ILLUMINA 54 · models Illumina HiSeq 2000 (54) · 83% of runs with a Sandpiper profile · first public 2017-06-21
Authors (46)
Kuang YS first · Lu JH · Li SH · Li JH · Yuan MY · He JR · Chen NN · Xiao WQ · Shen SY · Qiu L · Wu YF · Hu CY · Wu YY · Li WD · Chen QZ · Deng HW · Papasian CJ · Xia HM · Qiu X last · Tarracchini C first · Fontana F · Mancabelli L · Lugli GA · Alessandri G · Turroni F · Ventura M · Milani C last · Zorea A first · Pellow D · Levin L · Pilosof S · Friedman J · Shamir R · Mizrahi I last · Zhang K first · Hu M · Yang W · Hu Z · Rong Y · Luo B · Wang M · Cheng Y · Zhang R · Lv N · Zhou Q · Zhang X last
Downloads
PRJEB18755.csv.gz (2.6 KB) · parquet (72.7 KB) — all 54 samples, every field with route and confidence · PRJEB18755_determinations.csv.gz (4.3 KB) — 486 evidence rows