Gut microbiome in hypertension, case-control, China
117 fecal samples from adults and elderly individuals in China, comparing primary hypertension/cardiometabolic conditions and type 2 diabetes against healthy controls, using a case-control design. machine-written summary
117 samples · 117 runs · CN · Adult · 2022 · 5.44 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 664 sample values (collection date, country, health condition, health condition detail, latitude, longitude) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC10753005, PMC13001194, PMC13456470, PMC5573791 |
| ✓ Supplementary tables | 116 sample values (smoking status) |
| ✓ External resources | 386 sample values (age, bmi, health condition, health condition detail, sex) · from Meta2DB (LLNL) |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 107 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 117 | 100% | ||||
| country | 117 | 100% | 117 | |||
| health_condition | 117 | 100% | 98 | 19 | ||
| subject_id | 0 | 0% | ||||
| collection_date | 117 | 100% | 117 | |||
| health_condition_detail | 117 | 100% | 98 | 19 | ||
| latitude | 117 | 100% | 117 | |||
| longitude | 117 | 100% | 117 | |||
| age_at_collection_days | 116 | 99% | 116 | |||
| bmi | 116 | 99% | 116 | |||
| sex | 116 | 99% | 116 | |||
| smoking_status | 116 | 99% | 116 |
- Alterations of the Gut Microbiome in Hypertension. 2017 PMID 28884091 PMC5573791 own_data
- Antibiotic resistance profiles of gut microbiota across various primate species in Guangxi. 2023 PMID 38156010 PMC10753005 own_data
- A validation for sex differences in gut microbiome of essential hypertension based on cohort analysis. 2026 PMID 41654729 PMC13001194 own_data
- Hypertension and gut microbial hydrogenases: a comparison of hydrogen metabolism and etiology. 2026 PMID 42493771 PMC13456470 own_data
Archive description
Human gut microbiota is believed to be directly or indirectly involved in cardiovascular diseases and hypertension. However, the identification and functional status of the hypertension-related gut microbe(s) have not yet been surveyed in a comprehensive manner. Here we characterized the gut microbiome in hypertension status by comparing fecal samples of 60 patients with primary hypertension and 60 gender-, age-, and body weight-matched healthy controls based on whole-metagenome shotgun sequencing.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Alterations of the gut microbiome in hypertension”
- body site study.description · “Human gut microbiota is believed”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA14093500 | age_at_collection_days | 16071.0 | R2 | 0.70 | external.meta2db source | host_age: 44 |
| SAMEA14093500 | bmi | 25.8 | R2 | 0.70 | external.meta2db source | host_body_mass_index: 25.8 kilogram per meter squared |
| SAMEA14093500 | collection_date | 2015 | R1 | 0.90 | biosample.attribute:collection_date | 2015 |
| SAMEA14093500 | country | CN | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | China |
| SAMEA14093500 | health_condition | cardiometabolic_other | R1 | 0.85 | biosample.attribute:description | gut metagenome of hypertensive patient |
| SAMEA14093561 | health_condition | type2_diabetes | R2 | 0.70 | external.meta2db source | type 2 diabetes |
| SAMEA14093500 | health_condition_detail | gut metagenome of hypertensive patient | R1 | 0.85 | biosample.attribute:description | gut metagenome of hypertensive patient |
| SAMEA14093561 | health_condition_detail | type 2 diabetes | R2 | 0.70 | external.meta2db source | type 2 diabetes |
| SAMEA14093500 | latitude | 39.0000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 39 122 |
| SAMEA14093500 | longitude | 122.0000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 39 122 |
| SAMEA14093500 | sex | male | R2 | 0.70 | external.meta2db source | host_sex: male |
| SAMEA14093500 | smoking_status | never | R2 | 0.80 | paper.supp.DataSheet1.docx[table1!Smoke (Y/N)] | N |
Sequencing
117 runs over 117 samples · mean 5.36 Gbp per run (median 5.44 Gbp, total 627.61 Gbp; 117 runs with a base count) · layout PAIRED 117 · platform ILLUMINA 117 · models Illumina HiSeq 2000 (117) · 91% of runs with a Sandpiper profile · first public 2022-04-18 – 2022-04-26
Authors (42)
Yan Q first · Gu Y · Li X · Yang W · Jia L · Chen C · Han X · Huang Y · Zhao L · Li P · Fang Z · Zhou J · Guan X · Ding Y · Wang S · Khan M · Xin Y · Li S · Ma Y last · Huang H first · Pang X · Que T · Chen P · Wu A · He M · Qiu H · Hu Y last · Wang P first · Yao Y · Yan K · Wang M · Liu X · Hu C · Dong Y · Li J last · Yi Y first · Xie F · Xia C · Zhao P · Liu M · Ma X · Chen J last
Downloads
PRJEB21612.csv.gz (4.5 KB) · parquet (75.8 KB) — all 117 samples, every field with route and confidence · PRJEB21612_determinations.csv.gz (12.3 KB) — 1,166 evidence rows