Probiotics and gut resistome in preterm infants, Norway
Longitudinal cohort of 184 fecal samples from preterm and term infants in Norway, studying how probiotic supplementation and antibiotic therapy affect gut microbiota and antibiotic resistome development. machine-written summary
184 samples · 184 runs · NO · Infant / toddler · 2019 · 1.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 368 sample values (collection date, country) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC6250747 |
| ✓ Supplementary tables | 24 sample values (timepoint) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Probiotic (live microorganisms; single strain or mixture) design observational_with_procedure · population preterm_nicu · Infloran (L. acidophilus + B. infantis) probiotic in extremely preterm infants
“probiotic supplementation” — abstract:30505830 (study level; per-sample arms are in the intervention column below)
Genera, mean relative abundance over 167 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 184 | 100% | 184 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 184 | 100% | 184 | |||
| timepoint_label | 24 | 13% | 24 |
- Effects of Probiotic Supplementation on the Gut Microbiota and Antibiotic Resistome Development in Preterm Infants. PMID 30505830 PMC6250747 curated
- Exploring Molecular Interactions between Human Milk Hormone Insulin and Bifidobacteria. PMID 37191543 PMC10269646 curated
- Metagenome-mining indicates an association between bacteriocin presence and strain diversity in the infant gut. PMID 37259063 PMC10230729 curated
- Taxonomic and metabolic development of the human gut microbiome across life stages: a worldwide metagenomic investigation. PMID 38441032 PMC11019788 curated
- (no title) curated
Archive description
Probiotic supplementation was introduced as standard of care to prevent necrotizing enterocolitis (NEC) in extremely preterm infants in Norway. We aimed to evaluate the influence of probiotics and antibiotic therapy on the developing gut microbiota and antibiotic resistome in extremely preterm infants, and to compare with very preterm infants and term infants not given probiotics. Random shotgun metagenomic analysis was performed on the DNA isolated from the fecal samples. Our findings shows that probiotic supplementation may induce colonization resistance and alleviate harmful effects of antibiotics on the gut microbiota and antibiotic resistome
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler and neonate by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “supplementation on the gut microbiota and antibiotic”
- body site study.description · “on the developing gut microbiota and antibiotic”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.title · “development in preterm infants”
- life stage study.title · “resistome development in preterm infants”
- life stage study.description · “(NEC) in extremely preterm infants in Norway.”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA5216009 | collection_date | 2016 | R1 | 0.85 | biosample.attribute:collection_date | 2016 |
| SAMEA5216009 | country | NO | R1 | 0.90 | biosample_attr | Norway |
| SAMEA5216054 | timepoint_label | 0 - 1 month | R2 | 0.75 | paper.supp.table | AGE GROUP G12=0 - 1 month |
Sequencing
184 runs over 184 samples · mean 1.15 Gbp per run (median 1.14 Gbp, total 211.94 Gbp; 184 runs with a base count) · layout PAIRED 184 · platform ILLUMINA 184 · models Illumina MiSeq (184) · 91% of runs with a Sandpiper profile · first public 2019-01-14
Authors (40)
Esaiassen E first · Hjerde E · Cavanagh JP · Pedersen T · Andresen JH · Rettedal SI · Støen R · Nakstad B · Willassen NP · Klingenberg C last · Rizzo SM first · Alessandri G · Lugli GA · Fontana F · Tarracchini C · Mancabelli L · Viappiani A · Bianchi MG · Bussolati O · van Sinderen D · Ventura M · Turroni F last · Ormaasen I first · Rudi K · Diep DB · Snipen L last · Milani C · De Biase R · Bocchio F · De Conto F · Nouvenne A · Ticinesi A · Meschi T · Cecchi R · Yin Q first · da Silva AC · Zorrilla F · Almeida AS · Patil KR · Almeida A last
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata
Downloads
PRJEB29052.csv.gz (5.4 KB) · parquet (76.7 KB) — all 184 samples, every field with route and confidence · PRJEB29052_determinations.csv.gz (2.4 KB) — 392 evidence rows