Oral-gut metagenomics in liver cirrhosis, UK cohort
96 samples from the United Kingdom in a case-control study pairing oral and fecal metagenomics to examine microbial translocation and metabolic changes associated with liver cirrhosis. machine-written summary
96 samples · 273 runs · GB · Age unknown · 2021 · 2.63 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 192 sample values (country, subject id) |
| ✓ Abstract / description | 96 sample values (health condition detail) |
| ○ Full text | read; no usable statement or table · PMC13377410 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design observational_with_procedure
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 96 | 100% | 96 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 96 | 100% | 96 | |||
| health_condition_detail | 96 | 100% | 96 |
- Integrative host-microbiome modeling uncovers the implication of oral-gut translocation in advanced cirrhosis. 2026 PMID 42491347 PMC13377410 unsure
Archive description
TwinUK cohort
How this project entered the registry
Classified as human oral cavity / gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.57. Assay shotgun_dna.
- host run.scientific_name · “human oral metagenome”
- body site run.scientific_name · “human oral metagenome”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA7332273 | country | GB | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | United Kingdom |
| SAMEA7332273 | health_condition_detail | mixed_case_control: cirrhosis patients vs controls | R4 | 0.40 | paper.abstract | Translocation-associated microbial species enriched in patients with cirrhosis |
| SAMEA7332273 | subject_id | 01 | R1 | 0.70 | sample.name_rule:alias | TW_01_ST |
Sequencing
273 runs over 96 samples · mean 0.72 Gbp per run (median 0.48 Gbp, total 197.52 Gbp; 273 runs with a base count) · layout SINGLE 273 · platform ION_TORRENT 273 · models Ion Torrent Proton (273) · 0% of runs with a Sandpiper profile · first public 2021-08-09
Authors (22)
Jin Y first · Clasen F · Garcia-Guevara F · Arif S · Schierwagen R · Bidkhori G · Praktiknjo M · Brol MJ · Uschner FE · Castelli FA · Pons N · Quinquis B · Galleron N · Da Silva K · Junot C · Shawcross DL · Moyes DL · Jalan R · Ehrlich SD · Patel VC · Trebicka J · Shoaie S last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJEB38483.csv.gz (3.4 KB) · parquet (72.8 KB) — all 96 samples, every field with route and confidence · PRJEB38483_determinations.csv.gz (2.6 KB) — 288 evidence rows