Gut metagenome in imidazole propionate & diabetes (MetaCardis)
Shotgun metagenomic sequencing of gut DNA from 1,018 participants (France, Denmark, Germany) in the MetaCardis cohort, spanning cardiometabolic disease, type 2 diabetes, obesity and healthy controls, to examine microbial imidazole propionate production. machine-written summary
1,018 samples · 5,024 runs · FR, DK, DE · Age unknown · 2020 · 2.95 Gbp / sample · cohort Evidence of a causal and modifiable relationship b
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 551 sample values (country) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 2,036 sample values (antibiotic exposure, collection date) · PMC10511707, PMC12363224, PMC12795280, PMC13079829, PMC13172010, PMC13377033, PMC7676231, PMC8863577, PMC9664128 |
| ✓ Supplementary tables | 5,706 sample values (age, bmi, country, health condition, health condition detail, medication, medication detail, sex) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 445 | 44% | ||||
| country | 1,018 | 100% | 551 | 467 | ||
| health_condition | 974 | 96% | 974 | |||
| subject_id | 974 | 96% | 974 | |||
| antibiotic_exposure | 1,018 | 100% | 1,018 | |||
| collection_date | 1,018 | 100% | 1,018 | |||
| health_condition_detail | 974 | 96% | 974 | |||
| age_at_collection_days | 467 | 46% | 467 | |||
| sex | 467 | 46% | 467 | |||
| medication | 462 | 45% | 462 | |||
| medication_detail | 462 | 45% | 462 | |||
| bmi | 459 | 45% | 459 |
- Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology. 2020 PMID 33208748 PMC7676231 unsure
- Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism. 2022 PMID 35017197 PMC9664128 unsure
- Microbiome and metabolome features of the cardiometabolic disease spectrum. 2022 PMID 35177860 PMC8863577 unsure
- Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide. 2023 PMID 37730687 PMC10511707 unsure
- Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes. 2024 PMID 38918632 PMC11620793 unsure
7 more
- Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization. 2025 PMID 40742180 PMC12363224
- Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes. 2025 PMID 41408736 PMC12795280
- A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. 2026 PMID 41786749 PMC13079829
- CroCoDeEL: accurate control-free detection of cross-sample contamination in metagenomic data. 2026 PMID 42103726 PMC13377033
- Network topology of the gut microbiome associates with metabolic health in obesity. 2026 PMID 42129189 PMC13172010
- A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. 2025
- Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamineN-oxide with implications for heart and kidney disorders 2022
Archive description
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by curator_audit with confidence 0.60. Assay shotgun_dna.
- host runs.scientific_name · “human gut metagenome (5024)”
- host biosample_attributes.human_gut_environmental_package · “human-gut (1018)”
- body site runs.scientific_name · “human gut metagenome (5024)”
- body site biosample_attributes.human_gut_environmental_package · “human-gut (1018)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA7288155 | age_at_collection_days | 20819.2 | R2 | 0.85 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST9!Age (years)] | Age (years) 57 |
| SAMEA7288155 | antibiotic_exposure | no | R3 | 0.70 | paper.body.methods | that had received a recent antibiotic treatment (<2 months) were not included |
| SAMEA7288155 | bmi | 27.72 | R2 | 0.85 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST9!BMI (kg/m²)] | BMI 27.71967 |
| SAMEA7288155 | collection_date | 2013/2015 | R3 | 0.70 | paper.body.methods | Subjects were recruited between 2013 and 2015 |
| SAMEA7288156 | country | FR | R1 | 0.70 | sample.name_rule:alias | M0x10MCx1138 |
| SAMEA7288155 | country | FR | R2 | 0.85 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST9!Nationality] | Nationality France |
| SAMEA7288155 | health_condition | cardiometabolic_other | R2 | 0.85 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST9!Status] | Status MMC269|MMC372 |
| SAMEA7288155 | health_condition_detail | metabolically matched control (matched to IHD on T2D status and BMI); diabetic status Yes | R2 | 0.85 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST9!Status] | Status MMC269|MMC372; Diabetic status Yes |
| SAMEA7288155 | medication | antidiabetic_other;metformin | R2 | 0.80 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST14!drug columns] | Antidiabetic drugs; Insulin; Metformin; DPP IV inhibitors |
| SAMEA7288155 | medication_detail | Antidiabetic drugs; Insulin; Metformin; DPP IV inhibitors | R2 | 0.80 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST14!drug columns] | Antidiabetic drugs; Insulin; Metformin; DPP IV inhibitors |
| SAMEA7288155 | sex | male | R2 | 0.85 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST9!Gender] | Gender Male |
| SAMEA7288155 | subject_id | x10MCx1135 | R2 | 0.85 | paper.supp.41591_2022_1688_MOESM3_ESM.xlsx[ST9!ID] | x10MCx1135 |
Sequencing
5,024 runs over 1,018 samples · mean 0.62 Gbp per run (median 0.60 Gbp, total 3,127.15 Gbp; 5,024 runs with a base count) · layout SINGLE 5,024 · platform ION_TORRENT 5,024 · models Ion Torrent Proton (5,024) · 0% of runs with a Sandpiper profile · first public 2020-09-03
Authors (128)
Tang G first · Carr AV · Perez C · Ramos Sarmiento K · Levy L · Lampe JW · Diener C · Gibbons SM last · Chechi K first · Chakaroun R · Myridakis A · Forslund-Startceva SK · Fromentin S · Nielsen T · Aron-Wisneswky J · Belda E · Prifti E · Lassen PB · Falony G · Vieira-Silva S · Chilloux J · Sonomura K · Hoyles L · Martinez-Gili L · Pallotti F · Andrikopoulos P · Puig-Castellví F · Tapia RP · Castro-Dionicio I · Roume H · Pons N · Le Chatelier E · Quinquis B · Galleron N · Berland M · Olanipekun MT · Jia M · Manolias A · Holmes B · Adriouch S · Blüher M · Coelho LP · Da Silva K · Galan P · Ji B · Neves AL · Rouault C · Salem JE · Tremaroli V · Hansen TH · Søndertoft NB · Lewinter C · Pedersen HK · MetaCardis Consortium · Mark PD · Goetze JP · Køber L · Vestergaard H · Hansen T · Zucker JD · Sato TA · Hercberg S · Bäckhed F · Letunic I · Oppert JM · Nielsen J · Raes J · Tzoulaki I · Dehghan A · Zuber V · Bouzigon E · Lathrop M · Raina P · Froguel P · Matsuda F · Demenais F · Gauguier D · Stumvoll M · Bork P · Pedersen O · Ehrlich SD · Clément K · Dumas ME last · Goulet L first · Plaza Oñate F · Famechon A · Gautreau G last · Lacruz-Pleguezuelos B first · Pérez-Cuervo A · Coleto-Checa D · Bazán GX · Romero-Tapiador S · Freixer G · Fernández-Cabezas J · Aguilar-Aguilar E · Martín-Segura A · Cárdenas-Roig N · Carrasco-Guijarro L · Fernández LP · Espinosa-Salinas I · Ramírez de Molina A · Morales A · Tolosana R · Ortega-Garcia J · Pancaldi V · Marcos-Zambrano LJ · Carrillo de Santa Pau E last · Schroer HW first · Beghini F · Raygoza Garay JA · Christakis NA · Bosch DE last · Aron-Wisnewsky J · Forslund SK · Salem J · Andreelli F · Kieswich J · Puig-Castellvi F · Chevalier M · Alves R · Helft G · Isnard R · Pedro Coelho L · Gøtze JP · Zucker J · Oppert J · Yaqoob MM · Dumas M last
Downloads
PRJEB38742.csv.gz (36.3 KB) · parquet (126.7 KB) — all 1,018 samples, every field with route and confidence · PRJEB38742_determinations.csv.gz (88.9 KB) — 8,293 evidence rows