Gut microbiome in cirrhosis and ACLF, Spain, case-control
182 stool samples from patients with cirrhosis (compensated, decompensated, or with acute-on-chronic liver failure) and healthy controls in Spain, analyzed by quantitative metagenomics in a case-control design. machine-written summary
182 samples · 802 runs · ES · Age unknown · 2020 · 3.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 398 sample values (country, health condition, health condition detail) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| ✓ External resources | 148 sample values (health condition, health condition detail) · from GMrepo v3 |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
Schedule stated by the source: “Repeated stool sampling per patient implied by group 'ACLF_Follow_up' and numbered library names for same alias root (e.g. DURA_002_2,_3,_4); no stated interval/schedule.”.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 182 | 100% | 182 | |||
| health_condition | 182 | 100% | 108 | 74 | ||
| subject_id | 0 | 0% | ||||
| health_condition_detail | 182 | 100% | 108 | 74 |
- Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis. 2021 PMID 32941879 own_data
Archive description
Alterations in gut microbiome in cirrhosis as assessed by quantitative metagenomics. Relationship with acute-on-chronic liver failure and mortality and prognosis.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.80. Assay shotgun_dna.
- host run.scientific_name · “human gut metagenome”
- host study.title · “gut microbiome in cirrhosis”
- body site study.title · “Alterations in gut microbiome in cirrhosis”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA7336348 | country | ES | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Spain |
| SAMEA7336350 | health_condition | liver_disease | R1 | 0.90 | biosample_attr | ACLF |
| SAMEA7336396 | health_condition | liver_disease | R1 | 0.85 | biosample.attribute:group | Decompensated |
| SAMEA7336348 | health_condition | liver_disease | R2 | 0.75 | external.gmrepo source | phenotype: Liver Cirrhosis |
| SAMEA7336350 | health_condition_detail | ACLF | R1 | 0.85 | biosample.attribute:group | ACLF |
| SAMEA7336348 | health_condition_detail | Liver Cirrhosis | R2 | 0.75 | external.gmrepo source | phenotype: Liver Cirrhosis |
Sequencing
802 runs over 182 samples · mean 0.70 Gbp per run (median 0.60 Gbp, total 561.91 Gbp; 802 runs with a base count) · layout SINGLE 802 · platform ION_TORRENT 802 · models Ion Torrent Proton (802) · 0% of runs with a Sandpiper profile · first public 2020-10-08
Authors (23)
Solé C first · Guilly S · Da Silva K · Llopis M · Le-Chatelier E · Huelin P · Carol M · Moreira R · Fabrellas N · De Prada G · Napoleone L · Graupera I · Pose E · Juanola A · Borruel N · Berland M · Toapanta D · Casellas F · Guarner F · Doré J · Solà E · Ehrlich SD · Ginès P last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, subject_id. Share metadata
Downloads
PRJEB40200.csv.gz (5.0 KB) · parquet (75.8 KB) — all 182 samples, every field with route and confidence · PRJEB40200_determinations.csv.gz (4.0 KB) — 546 evidence rows