Gut microbiome in schizophrenia vs metabolic syndrome, Denmark
132 fecal samples from a Danish case-control study comparing gut microbiota of schizophrenia patients to healthy controls and individuals with metabolic syndrome, examining links to cognitive function. machine-written summary
132 samples · 321 runs · DK · Adult · 2022 · 2.78 Gbp / sample · cohort Alteration of Gut Microbiome in Patients With Schi
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 264 sample values (country, subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC10140391 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 132 | 100% | ||||
| country | 132 | 100% | 132 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 132 | 100% | 132 |
- Alteration of Gut Microbiome in Patients With Schizophrenia Indicates Links Between Bacterial Tyrosine Biosynthesis and Cognitive Dysfunction. 2023 PMID 37124355 PMC10140391 unsure
Archive description
Schizophrenia (SCZ) is a heterogeneous neuropsychiatric disorder, for which current treatment has insufficient efficacy and severe adverse effects. The modifiable gut microbiome might be a potential target for intervention to improve neurobiological functions through the gut-microbiome-brain axis. In this case-control study, gut microbiota of 132 patients with SCZ and increased waist circumference was compared to gut microbiota of two age- and sex-matched control groups, comprising 132 healthy individuals (HC) (see PRJEB41786 and PRJEB41787 repositories) and 132 individuals with metabolic syndrome (MS). Shotgun sequencing was used to characterize fecal samples at taxonomic and functional level. Cognition of the SCZ patients was evaluated using the Brief Assessment of Cognition instrument. SCZ gut microbiota differed significantly from those of HC and MS in terms of richness and global composition. SCZ gut microbiota was notably enriched in Flavonifractor plautii, Collinsella aerofaciens, Bilophila wadsworthia and Sellimonas intestinalis, while depleted in Faecalibacterium prausnitzii, Ruminococcus lactaris, Ruminococcus bicirculans and Veillonella rogosae. Functional potential of the gut microbiota accounted for 11% of the cognition variability. In particular, the bacterial functional module for synthesizing tyrosine, a precursor for dopamine, was in SCZ cases positively associated to cognitive score (rho = 0.34, q ≤ 0.1). Overall, this study shows that the gut microbiome of SCZ patients differs greatly from that of healthy or MS controls. Cognitive function of SCZ patients is associated with the potential for gut bacterial biosynthesis of tyrosine, a precursor for dopamine, suggesting gut microbiota might be an intervention target for alleviation of cognitive dysfunction in SCZ.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Alteration of gut microbiome in patients”
- body site study.description · “effects. The modifiable gut microbiome might be”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA12687810 | country | DK | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Denmark |
| SAMEA12687810 | subject_id | Schizo_Change_1003 | R1 | 0.85 | biosample.attribute:alias | alias: Schizo_Change_1003 |
Sequencing
321 runs over 132 samples · mean 1.16 Gbp per run (median 0.65 Gbp, total 373.27 Gbp; 321 runs with a base count) · layout SINGLE 321 · platform ION_TORRENT 321 · models Ion Torrent Proton (321) · 0% of runs with a Sandpiper profile · first public 2022-01-31
Authors (23)
Thirion F first · Speyer H · Hansen TH · Nielsen T · Fan Y · Le Chatelier E · Fromentin S · Berland M · Plaza Oñate F · Pons N · Galleron N · Levenez F · Markó L · Birkner T · Jørgensen T · Forslund SK · Vestergaard H · Hansen T · Nordentoft M · Mors O · Benros ME · Pedersen O · Ehrlich SD last
Downloads
PRJEB41217.csv.gz (4.2 KB) · parquet (74.6 KB) — all 132 samples, every field with route and confidence · PRJEB41217_determinations.csv.gz (2.6 KB) — 264 evidence rows