Gut microbiome, drugs and cardiometabolic disease (MetaCardis)
41 gut metagenome samples from the European MetaCardis cohort, part of a cross-sectional study examining how medications and cardiometabolic disease shape the gut microbiome and serum metabolome. machine-written summary
41 samples · 216 runs · Age unknown · 2021 · 2.87 Gbp / sample · cohort Evidence of a causal and modifiable relationship b
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 41 sample values (subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC10511707, PMC12363224, PMC12795280, PMC13079829, PMC13172010, PMC8863577, PMC9664128 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 0 | 0% | ||||
| health_condition | 0 | 0% | ||||
| subject_id | 41 | 100% | 41 |
- Combinatorial, additive and dose-dependent drug-microbiome associations. 2021 PMID 34880489 own_data
- Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism. 2022 PMID 35017197 PMC9664128 unsure
- Microbiome and metabolome features of the cardiometabolic disease spectrum. 2022 PMID 35177860 PMC8863577 unsure
- Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide. 2023 PMID 37730687 PMC10511707 unsure
- Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes. 2024 PMID 38918632 PMC11620793 unsure
6 more
- Metagenomic estimation of absolute bacterial biomass in the mammalian gut through host-derived read normalization. 2025 PMID 40742180 PMC12363224
- Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes. 2025 PMID 41408736 PMC12795280
- A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. 2026 PMID 41786749 PMC13079829
- Network topology of the gut microbiome associates with metabolic health in obesity. 2026 PMID 42129189 PMC13172010
- A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. 2025
- Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamineN-oxide with implications for heart and kidney disorders 2022
Archive description
Medication signatures dominate microbiome and metabolome alterations in cardiometabolic diseases
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.60. Assay shotgun_dna.
- host run.scientific_name · “human gut metagenome”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA7597993 | subject_id | MCx1349 | R1 | 0.60 | sample.name_rule:alias | M0x10MCx1349 |
Sequencing
216 runs over 41 samples · mean 0.58 Gbp per run (median 0.56 Gbp, total 124.52 Gbp; 216 runs with a base count) · layout SINGLE 216 · platform ION_TORRENT 216 · models Ion Torrent Proton (216) · 0% of runs with a Sandpiper profile · first public 2021-08-10
Authors (134)
Forslund SK first · Chakaroun R · Zimmermann-Kogadeeva M · Markó L · Aron-Wisnewsky J · Nielsen T · Moitinho-Silva L · Schmidt TSB · Falony G · Vieira-Silva S · Adriouch S · Alves RJ · Assmann K · Bastard JP · Birkner T · Caesar R · Chilloux J · Coelho LP · Fezeu L · Galleron N · Helft G · Isnard R · Ji B · Kuhn M · Le Chatelier E · Myridakis A · Olsson L · Pons N · Prifti E · Quinquis B · Roume H · Salem JE · Sokolovska N · Tremaroli V · Valles-Colomer M · Lewinter C · Søndertoft NB · Pedersen HK · Hansen TH · MetaCardis Consortium* · Gøtze JP · Køber L · Vestergaard H · Hansen T · Zucker JD · Hercberg S · Oppert JM · Letunic I · Nielsen J · Bäckhed F · Ehrlich SD · Dumas ME · Raes J · Pedersen O · Clément K · Stumvoll M · Bork P last · Tang G first · Carr AV · Perez C · Ramos Sarmiento K · Levy L · Lampe JW · Diener C · Gibbons SM last · Chechi K first · Forslund-Startceva SK · Fromentin S · Aron-Wisneswky J · Belda E · Lassen PB · Sonomura K · Hoyles L · Martinez-Gili L · Pallotti F · Andrikopoulos P · Puig-Castellví F · Tapia RP · Castro-Dionicio I · Berland M · Olanipekun MT · Jia M · Manolias A · Holmes B · Blüher M · Da Silva K · Galan P · Neves AL · Rouault C · MetaCardis Consortium · Mark PD · Goetze JP · Sato TA · Tzoulaki I · Dehghan A · Zuber V · Bouzigon E · Lathrop M · Raina P · Froguel P · Matsuda F · Demenais F · Gauguier D · Lacruz-Pleguezuelos B first · Pérez-Cuervo A · Coleto-Checa D · Bazán GX · Romero-Tapiador S · Freixer G · Fernández-Cabezas J · Aguilar-Aguilar E · Martín-Segura A · Cárdenas-Roig N · Carrasco-Guijarro L · Fernández LP · Espinosa-Salinas I · Ramírez de Molina A · Morales A · Tolosana R · Ortega-Garcia J · Pancaldi V · Marcos-Zambrano LJ · Carrillo de Santa Pau E last · Salem J · Andreelli F · Kieswich J · Puig-Castellvi F · Chevalier M · Alves R · Pedro Coelho L · Zucker J · Oppert J · Yaqoob MM · Dumas M last
Downloads
PRJEB41311.csv.gz (1.9 KB) · parquet (69.8 KB) — all 41 samples, every field with route and confidence · PRJEB41311_determinations.csv.gz (931 B) — 41 evidence rows