Gut microbiota and balneotherapy in atopic dermatitis, France
192 stool samples from atopic dermatitis patients in France, collected before and after a 3-week balneotherapy intervention at La Roche-Posay, analyzed by shotgun metagenomic sequencing. machine-written summary
192 samples · 819 runs · FR · Adult · 2022 · 2.99 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,152 sample values (age, country, intervention, sex, subject id, timepoint) |
| ✓ Abstract / description | 192 sample values (health condition detail) |
| ✓ Full text | 768 sample values (collection date, health condition, location locality, location site) · PMC8818552 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
96 people have samples in more than one arm.
Other administered intervention (see intervention_detail) design single_arm_before_after · population allergy_or_atopy · 3-week balneotherapy (thermal spring water treatment)
“Stool samples were collected prior and post a 3-week balneotherapy” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal
96 of 96 people sampled more than once (192 samples; median 2, up to 2 per person) · follow-up median 18 d (max 18 d) · median interval between samples 18 d (time from visit codes mapped to the stated schedule). Schedule stated by the source: “stool at baseline (T0) and at end of 18-day balneotherapy (T18)” (time origin: intervention_start); stated follow-up 18 d.
Each row is one person (36 shown of 96); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 192 | 100% | ||||
| country | 192 | 100% | 192 | |||
| health_condition | 192 | 100% | 192 | |||
| subject_id | 192 | 100% | 192 | |||
| age_at_collection_days | 192 | 100% | 192 | |||
| collection_date | 192 | 100% | 192 | |||
| detailed_location | 192 | 100% | ||||
| health_condition_detail | 192 | 100% | 192 | |||
| intervention | 192 | 100% | 192 | |||
| location_locality | 192 | 100% | 192 | |||
| location_site | 192 | 100% | 192 | |||
| sex | 192 | 100% | 192 | |||
| timepoint_label | 192 | 100% | 192 |
- Changes in Gut Microbiota of Patients with Atopic Dermatitis During Balneotherapy. 2022 PMID 35140493 PMC8818552 own_data
Archive description
Balneotherapy (BT) is the treatment of disease through the use of thermal spring water (TSW). It has been used for centuries and remains a popular form of treatment for dermatologic diseases such as atopic dermatitis (AD). Recent findings highlighted the role of the gut microbiota in AD and the possible crosstalk between gut and skin microbiomes in this pathology. Nevertheless, changes in the composition of the gut microbiota after balneotherapy remain to be elucidated. A total of 96 patients, with moderate to severe AD according to the SCORAD, were enrolled. Stool samples were collected prior and post a 3-week balneotherapy at the thermal care center of La Roche-Posay (France). Composition of the gut microbiota was assessed by shotgun metagenomic sequencing. Species associated with high gut microbiota richness tended to correlate negatively with disease severity (SCORAD) and positively with SCORAD reduction, while species associated with low richness displayed the opposite pattern. Relative abundance of 23 species was significantly altered during BT, these changes being significantly associated with SCORAD reduction during BT, suggesting that gut microbiota composition and AD progression were associated through the treatment. Microbial functions related to gut-brain axis such as GABA and tryptophan metabolism were also altered by the treatment. Long-standing AD patients exhibited a better gut microbial profile than recently diagnosed patients, with higher MSP richness and species associated with SCORAD reduction. In patients with AD, clinical disease parameters such as SCORAD or disease duration are intricately linked to the gut microbiota composition. SCORAD reduction occurring during BT was also associated with gut microbiota. The gut-brain-skin axis via neurotransmitter such as GABA should be further studied in diseases such as AD.
How this project entered the registry
Classified as human gut / stool / skin shotgun DNA metagenome of adult and adolescent by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Changes in gut microbiota during balneotherapy”
- body site study.description · “role of the gut microbiota in AD”
- body site study.description · “between gut and skin microbiomes in this”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage sample.attr.age · “15 (n=22/192)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA12693256 | age_at_collection_days | 23741.2 | R1 | 0.70 | sample.attr.age | 65 |
| SAMEA12693256 | collection_date | 2016-04/2016-09 | R3 | 0.70 | paper.fulltext.methods | conducted between April and September 2016 |
| SAMEA12693256 | country | FR | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | France |
| SAMEA12693256 | health_condition | allergy_or_atopy | R3 | 0.70 | paper.fulltext.methods | suffering from AD |
| SAMEA12693256 | health_condition_detail | atopic dermatitis, moderate to severe | R4 | 0.50 | study.description | 96 patients, with moderate to severe AD |
| SAMEA12693256 | intervention | no_intervention | R1 | 0.85 | biosample.attribute:time | T0 |
| SAMEA12693256 | location_locality | La Roche-Posay | R3 | 0.70 | paper.fulltext.methods | thermal care center of La Roche-Posay (France) |
| SAMEA12693256 | location_site | Thermal care center of La Roche-Posay | R3 | 0.70 | paper.fulltext.methods | thermal care center of La Roche-Posay (France) |
| SAMEA12693256 | sex | female | R1 | 0.90 | sample.attr.gender | F |
| SAMEA12693256 | subject_id | 1 | R1 | 0.85 | sample.attr.subject | 1 |
| SAMEA12693256 | timepoint_label | T0 | R1 | 0.85 | sample.attr.time | T0 |
Sequencing
819 runs over 192 samples · mean 0.71 Gbp per run (median 0.69 Gbp, total 579.70 Gbp; 819 runs with a base count) · layout SINGLE 819 · platform ION_TORRENT 819 · models Ion Torrent Proton (819) · 0% of runs with a Sandpiper profile · first public 2022-01-30
Authors (13)
Thirion F first · Guilly S · Fromentin S · Plaza Oñate F · Alvarez AS · Le Chatelier E · Pons N · Levenez F · Quinquis B · Ehrlich S · Doré J · Martin R · Seité S last
Downloads
PRJEB43611.csv.gz (6.8 KB) · parquet (78.9 KB) — all 192 samples, every field with route and confidence · PRJEB43611_determinations.csv.gz (13.2 KB) — 2,112 evidence rows