Berberine/Bifidobacterium gut microbiota in hyperglycemia (China)
Multi-centre, double-blind randomised trial of berberine and/or Bifidobacterium in adults with hyperglycaemia in Shaanxi, China: 208 stool shotgun metagenomes from 104 participants (two samples each). machine-written summary
208 samples · 208 runs · CN · Age unknown · 2021 · 2.99 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 624 sample values (collection date, country, subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC8351344 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin Probiotic (live microorganisms; single strain or mixture) design randomized_controlled_trial · population type2_diabetes · Berberine and/or Bifidobacterium vs placebo, 16-week RCT
“randomized, double-blind, parallel-controlled study of patients newly diagnosed with hyperglycemia” — abstract:34365978 (study level; per-sample arms are in the intervention column below)
longitudinal
104 of 104 people sampled more than once (208 samples; median 2, up to 2 per person) · follow-up median 4 mo (max 9 mo) · median interval between samples 4 mo (time from collection dates). Schedule stated by the source: “baseline (post run-in) and after 16 weeks of treatment” (time origin: unknown).
Each row is one person (36 shown of 104); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 208 | 100% | 208 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 208 | 100% | 208 | |||
| collection_date | 208 | 100% | 208 |
- Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. 2021 PMID 34365978 PMC8351344 own_data
Archive description
Berberine and Bifidobacterium have been reported to improve glucose tolerance in people with hyperglycemia or other metabolic disorders. This study aimed to assess the hypoglycemic effect of berberine’s and Bifidobacterium’s hypoglycemic effect and regulation of the gut microbiota, and the possible additive benefits of combination.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by curator_audit with confidence 0.50. Assay shotgun_dna.
- host runs.scientific_name · “human gut metagenome”
- host papers[0].abstract · “patients newly diagnosed with hyperglycemia”
- body site runs.scientific_name · “human gut metagenome”
- body site papers[0].abstract · “patients newly diagnosed with hyperglycemia”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA8740346 | collection_date | 2016-05-17 | R1 | 0.85 | biosample.attribute:collection_date | 2016-05-17 |
| SAMEA8740346 | country | CN | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | China |
| SAMEA8740346 | subject_id | 010007 | R1 | 0.70 | sample.name_rule:sample_descript | S010007_T |
Sequencing
208 runs over 208 samples · mean 2.91 Gbp per run (median 2.99 Gbp, total 604.98 Gbp; 208 runs with a base count) · layout PAIRED 208 · platform ILLUMINA 208 · models Illumina NovaSeq 6000 (208) · 91% of runs with a Sandpiper profile · first public 2021-05-13
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJEB44907.csv.gz (6.3 KB) · parquet (77.8 KB) — all 208 samples, every field with route and confidence · PRJEB44907_determinations.csv.gz (6.3 KB) — 624 evidence rows