Fiber-enriched bread & gut microbiota, cardiometabolic risk
156 stool samples from adults (and a few elderly) in France with cardiometabolic risk, studied in a double-blind, randomized, cross-over trial comparing standard bread versus a 7-dietary-fiber-enriched bread over two 8-week periods. machine-written summary
156 samples · 1,065 runs · FR · Adult · 2021 · 3.09 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,092 sample values (age, bmi, country, intervention, sex, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 624 sample values (collection date, health condition, health condition detail, location site) · PMC8942430 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Controlled / prescribed diet or feeding regimen Prebiotic / dietary fibre supplement design crossover · population cardiometabolic_other · Daily 150g bread: standard (5.55g fiber) vs 7-fiber-enriched (16.05g fiber), 8-week crossover
“daily 150 g of standard bread or enriched with a 7-dietary fiber” — abstract:35311446 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
39 of 39 people sampled more than once (156 samples; median 4, up to 4 per person). Schedule stated by the source: “Stool at V2 (baseline) and V4 (end of 8-wk period1); V5 (baseline period2) and V7 (end of 8-wk period2), cross-over trial” (time origin: intervention_start).
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 156 | 100% | ||||
| country | 156 | 100% | 156 | |||
| health_condition | 156 | 100% | 156 | |||
| subject_id | 156 | 100% | 156 | |||
| age_at_collection_days | 156 | 100% | 156 | |||
| bmi | 156 | 100% | 156 | |||
| collection_date | 156 | 100% | 156 | |||
| detailed_location | 156 | 100% | ||||
| health_condition_detail | 156 | 100% | 156 | |||
| intervention | 156 | 100% | 156 | |||
| location_site | 156 | 100% | 156 | |||
| sex | 156 | 100% | 156 | |||
| timepoint_label | 156 | 100% | 156 |
- Increasing the diversity of dietary fibers in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk. 2022 PMID 35311446 PMC8942430 own_data
Archive description
Increasing the diversity of dietary fibres in a daily-consumed bread modifies gut microbiota and metabolic profile in subjects at cardiometabolic risk
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “daily-consumed bread modifies gut microbiota and metabolic”
- body site study.description · “daily-consumed bread modifies gut microbiota and metabolic”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA10983845 | age_at_collection_days | 17166.8 | R1 | 0.70 | sample.attr.age | 47 |
| SAMEA10983845 | bmi | 28.68 | R1 | 0.90 | sample.attr.bmi | 28.68 |
| SAMEA10983845 | collection_date | 2017-11/2018-07 | R3 | 0.70 | paper.fulltext.methods | included in this study between November 2017 and July 2018 |
| SAMEA10983845 | country | FR | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | France |
| SAMEA10983845 | health_condition | cardiometabolic_other | R3 | 0.70 | paper.fulltext.methods | subjects with CMR profile were included |
| SAMEA10983845 | health_condition_detail | subjects with cardiometabolic risk (CMR) profile | R3 | 0.70 | paper.fulltext.methods | subjects with CMR profile were included |
| SAMEA10983845 | intervention | no_intervention | R1 | 0.85 | biosample.attribute:bread | CTL |
| SAMEA10983845 | location_site | Human Nutrition Research Center of Rhône-Alpes (CRNH-RA) | R3 | 0.70 | paper.fulltext.methods | conducted at the Human Nutrition Research Center of Rhône-Alpes |
| SAMEA10983845 | sex | female | R1 | 0.90 | sample.attr.gender | F |
| SAMEA10983845 | subject_id | 5 | R1 | 0.85 | sample.attr.individual | 5 |
| SAMEA10983845 | timepoint_label | V2 | R1 | 0.85 | sample.attr.visit | V2 |
Sequencing
1,065 runs over 156 samples · mean 0.46 Gbp per run (median 0.44 Gbp, total 491.22 Gbp; 1,065 runs with a base count) · layout SINGLE 1,065 · platform ION_TORRENT 1,065 · models Ion Torrent Proton (1,065) · 0% of runs with a Sandpiper profile · first public 2021-11-17
Authors (19)
Ranaivo H first · Thirion F · Béra-Maillet C · Guilly S · Simon C · Sothier M · Van Den Berghe L · Feugier-Favier N · Lambert-Porcheron S · Dussous I · Roger L · Roume H · Galleron N · Pons N · Le Chatelier E · Ehrlich SD · Laville M · Doré J · Nazare JA last
Downloads
PRJEB48663.csv.gz (5.9 KB) · parquet (78.0 KB) — all 156 samples, every field with route and confidence · PRJEB48663_determinations.csv.gz (12.6 KB) — 1,716 evidence rows