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PRJEB49124 ERP133586

Gut metagenomes of Singaporean octogenarians, SG90 cohort

Gut metagenomes of Asian octogenarians from SG90 cohort

233 stool-sample shotgun metagenomes from community-living octogenarians in Singapore (SG90 cohort), a cross-sectional study of gut microbiome associations with healthy aging. machine-written summary

234 samples · 234 runs · SG · Elderly · 2021 · 1.12 Gbp / sample

Sources
○Sequence archive○Abstract / description✓Full text 935✓Supplementary tables 469–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
○ Sequence archiverecords read; no usable sample values
○ Abstract / descriptionread; no usable statement
✓ Full text935 sample values (country, health condition, health condition detail, subject id) · PMC11377447
✓ Supplementary tables469 sample values (age, sex, subject id)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 country
Age
elderly234
Condition
healthy_control234
Sex
female139
male95
Country
SG234
Body site
primary234
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)this project, 0.1–0.3 Gbp: 2 samplesall projects, 0.3–1 Gbp: 47,044 samples (8 %)this project, 0.3–1 Gbp: 83 samplesall projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 148 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 1 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 1.12 Gbp per sample0130Gbp
Community composition
Bacteroides 25.0%Phocaeicola 11.2%Prevotella 9.7%Alistipes 9.5%Escherichia 3.1%Parabacteroides 3.0%Faecalibacterium 1.4%Vescimonas 1.4%Bifidobacterium 1.2%Roseburia 1.2%Fimenecus 0.9%Sutterella 0.8%not assigned to a genus 15.1%other genera 16.7%

Genera, mean relative abundance over 211 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category234 100%
country234 100%234
health_condition234 100%234
subject_id234 100%1233
age_at_collection_days234 100%234
health_condition_detail234 100%234
sex234 100%234
Papers (1)
  • Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes. 2024 PMID 39237540 PMC11377447 own_data
Details
Archive description

Shotgun metagenomics of stool samples from the ageing population of SG90 cohort

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of elderly by sonnet_x2 with confidence 0.65. Assay shotgun_dna.

  • host study.title · “Gut metagenomes of Asian octogenarians”
  • body site study.description · “stool samples from the ageing population”
  • life stage study.title · “Asian octogenarians from SG90 cohort”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMEA10830270age_at_collection_days29220R20.85paper.supp.41467_2024_52097_MOESM4_ESM.xlsx[Metadata!Age (in years)]80
SAMEA10830270countrySGR30.70paper.fulltext.abstractcommunity-living octogenarians in Singapore
SAMEA10830270health_conditionhealthy_controlR30.70paper.fulltext.methodsnot living in a nursing home, no diagnosis of dementia
SAMEA10830270health_condition_detailcommunity-living participants not living in a nursing homeR30.70paper.fulltext.methodsnot living in a nursing home, no diagnosis of dementia
SAMEA10830270sexfemaleR20.85paper.supp.41467_2024_52097_MOESM4_ESM.xlsx[Metadata!Gender]Female
SAMEA10830347subject_idMBS1460R20.85paper.supp.41467_2024_52097_MOESM4_ESM.xlsx[Metadata!Subject ID]MBS1460
SAMEA10830270subject_idSAMEA10830270R30.70design.one_sample_per_subject:fulltextThe current dataset is based on a subset of 234 elderly individuals (77–97 years old)
Sequencing

234 runs over 234 samples · mean 1.20 Gbp per run (median 1.12 Gbp, total 280.57 Gbp; 234 runs with a base count) · layout PAIRED 234 · platform ILLUMINA 234 · models HiSeq X Ten (184), Illumina HiSeq 2500 (50) · 91% of runs with a Sandpiper profile · first public 2021-12-07 – 2021-12-08

Authors (21)

Ravikrishnan A first · Wijaya I · Png E · Chng KR · Ho EXP · Ng AHQ · Mohamed Naim AN · Gounot JS · Guan SP · Hanqing JL · Guan L · Li C · Koh JY · de Sessions PF · Koh WP · Feng L · Ng TP · Larbi A · Maier AB · Kennedy BK · Nagarajan N last

Downloads

PRJEB49124.csv.gz (6.9 KB) · parquet (79.9 KB) — all 234 samples, every field with route and confidence · PRJEB49124_determinations.csv.gz (8.3 KB) — 1,404 evidence rows

Samples (234 · every field this project has values for · hover a cell for its source)
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