HBOT adjunct therapy in hospitalized UC patients, San Diego

Hyperbaric oxygen therapy (HBOT) markedly increases tissue oxygen delivery. Case series suggest it may have a potential therapeutic benefit in ulcerative colitis (UC). We investigated the therapeutic potential of HBOT as an adjunct to steroids for UC flares requiring hospitalization. Ulcerative colitis (UC) is a chronic inflammatory bowel disease which significantly affects the lives of nearly 1 million Americans. It is estimated that 25% of patients will need hospitalization for acute moderate to severe flares. Although colectomy is curative, it can be associated with significant morbidity, mortality and a reduction in quality of life. The mainstay of medical therapy for these patients is high dose intravenous steroids but approximately one-third of patients will be refractory and require second line rescue therapy with either cyclosporine or Infliximab, both of which are associated with a lack of significant efficacy in maintaining remission over the long term. Furthermore, corticosteroids have considerable long-term consequences and these immune suppressive drugs are associated with life-threatening infections and lymphomas. In an attempt to address this gap, we investigated the potential application of hyperbaric oxygen therapy (HBOT) as an adjunct to standard medical treatment. In a small phase 2A pilot study of 18 hospitalized UC patients, we were able to demonstrate a statistically significant increase in response, remission, and trend towards significance for avoidance of colectomy. We are now preparing for a phase 2B study in anticipation of a phase 3 registration trial and a multi-PI R01

Classified as human gut / stool / blood / tissue / internal fluids shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

• host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
• body site external_curation.infant_catalog · “body_site_call gut”
• body site study.description · “(HBOT) markedly increases tissue oxygen delivery. Case”
• life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”

84 runs over 84 samples · mean 0.54 Gbp per run (median 52.7 Mbp, total 45.63 Gbp; 84 runs with a base count) · layout PAIRED 84 · platform ILLUMINA 84 · models Illumina NovaSeq 6000 (84) · 5% of runs with a Sandpiper profile · first public 2022-01-19

No author record.

PRJEB50260.csv.gz (3.7 KB) · parquet (75.9 KB) — all 84 samples, every field with route and confidence · PRJEB50260_determinations.csv.gz (8.1 KB) — 1,057 evidence rows