Gut microbiome and dairy product intervention for sleep, Netherlands
Shotgun metagenomics of 134 human faecal samples from a Dutch intervention study assessing effects of a dairy-based product (whey protein, galacto-oligosaccharides, tryptophan, vitamins, minerals) on gut microbiota in adults with moderate sleep disturbances. machine-written summary
134 samples · 134 runs · NL · 2023 · 6.72 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ○ Sequence archive | records read; no usable sample values |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 134 sample values (country) · PMC8308271 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Non-microbial dietary supplement (vitamins Synbiotic (probiotic + prebiotic) · population other_disease · Dairy-based product with whey protein, galacto-oligosaccharides, tryptophan, vitamins/minerals vs skimmed milk placebo
“cross-over RCT (three weeks intervention; three weeks washout)” — abstract:34199006 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
Schedule stated by the source: “Fecal samples collected at day 0 and day 21 of the 1st intervention period only (3-week intervention).”; stated follow-up 21 d.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 134 | 100% | ||||
| country | 134 | 100% | 134 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% |
- The Effect of A Whey-Protein and Galacto-Oligosaccharides Based Product on Parameters of Sleep Quality, Stress, and Gut Microbiota in Apparently Healthy Adults with Moderate Sleep Disturbances: A Randomized Controlled Cross-Over Study. 2021 PMID 34199006 PMC8308271 own_data
- Gut microbiome composition and functionality impact the responsiveness to a dairy-based product containing galacto-oligosaccharides for improving sleep quality in adults. 2024 PMID 38897586 own_data
Archive description
Shotgun microbiome analysis of gut microbiome from a randomized clinical trial looking at the effect of a probiotic product on sleep quality compared to a placebo control (N=70, 35 vs 35).
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome by curator_audit with confidence 0.95. Assay shotgun_dna.
- host study_title · “sleep quality, stress, and gut-microbiota analyzed using shotgun metagenomics”
- host runs.scientific_name · “human gut metagenome (134)”
- body site study_title · “sleep quality, stress, and gut-microbiota analyzed using shotgun metagenomics”
- body site runs.scientific_name · “human gut metagenome (134)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA12674995 | country | NL | R3 | 0.70 | paper.body.methods | double-blind randomized placebo-controlled cross-over study in 70 apparently healthy Dutch adults |
Sequencing
134 runs over 134 samples · mean 7.31 Gbp per run (median 6.72 Gbp, total 979.09 Gbp; 134 runs with a base count) · layout PAIRED 134 · platform ILLUMINA 134 · models Illumina NovaSeq 6000 (134) · 93% of runs with a Sandpiper profile · first public 2023-01-03
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJEB50505.csv.gz (3.8 KB) · parquet (73.5 KB) — all 134 samples, every field with route and confidence · PRJEB50505_determinations.csv.gz (1003 B) — 134 evidence rows