Gut microbiome after duodenal ablation in type 2 diabetes
33 faecal samples from adults with type 2 diabetes undergoing duodenal mucosal resurfacing combined with GLP-1 receptor agonist therapy, collected at baseline and 3 months post-procedure in a longitudinal design. machine-written summary
33 samples · 33 runs · Adult · 2022 · 6.76 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 64 sample values (subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 66 sample values (health condition, health condition detail) · PMC10012157 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin Surgical procedure studied before/after (bariatric surgery design single_arm_before_after · population type2_diabetes · Duodenal mucosal resurfacing ablation + GLP-1 receptor agonist in T2DM
“duodenal mucosal ablation by the use of hydrothermal energy” — abstract:36992788 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
16 of 16 people sampled more than once (32 samples; median 2, up to 2 per person). Schedule stated by the source: “Faecal samples collected at baseline (1 week before DMR) and 3 months after DMR for each patient” (time origin: intervention_start).
Genera, mean relative abundance over 30 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 33 | 100% | ||||
| country | 0 | 0% | ||||
| health_condition | 33 | 100% | 33 | |||
| subject_id | 32 | 97% | 32 | |||
| health_condition_detail | 33 | 100% | 33 | |||
| timepoint_label | 32 | 97% | 32 |
- A Changed Gut Microbiota Diversity Is Associated With Metabolic Improvements After Duodenal Mucosal Resurfacing With Glucagon-Like-Peptide-1 Receptor Agonist in Type 2 Diabetes in a Pilot Study. 2022 PMID 36992788 PMC10012157 own_data
Archive description
INSPIRE is a study of duodenal mucosal resurfacing, through intestinal ablation, to investigate its potential for treatment of type 2 diabetes mellitus. In this study, the microbiome before and after intestinal ablation was studied in combination with a range of clinical markers.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “The effect of intestinal ablation on the”
- body site study.description · “a study of duodenal mucosal resurfacing, through”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA13060047 | health_condition | type2_diabetes | R3 | 0.70 | paper.fulltext.methods | 16 patients with T2DM using long-acting insulin |
| SAMEA13060047 | health_condition_detail | type 2 diabetes mellitus (T2DM) treated with insulin | R3 | 0.70 | paper.fulltext.methods | 16 patients with T2DM using long-acting insulin |
| SAMEA13060047 | subject_id | patient_3 | R1 | 0.70 | sample.name_rule:TITLE | patient_3_A |
| SAMEA13060047 | timepoint_label | A | R1 | 0.70 | sample.name_rule:TITLE | patient_3_A |
Sequencing
33 runs over 33 samples · mean 6.91 Gbp per run (median 6.76 Gbp, total 227.95 Gbp; 33 runs with a base count) · layout PAIRED 33 · platform ILLUMINA 33 · models unspecified (33) · 91% of runs with a Sandpiper profile · first public 2022-03-23 – 2022-03-24
Authors (7)
Meiring S first · van Baar ACG · Sørensen N · Holleman F · Soeters MR · Nieuwdorp M · Bergman JJGHM last
Downloads
PRJEB51010.csv.gz (1.7 KB) · parquet (70.2 KB) — all 33 samples, every field with route and confidence · PRJEB51010_determinations.csv.gz (1.7 KB) — 130 evidence rows