Healthy women at sea level vs high altitude, gut metagenome
Pilot study of fecal metagenomes from 48 healthy women, 30 living at sea level and 18 in high-altitude areas, comparing gut microbiota to explore high-altitude adaptation. machine-written summary
17 samples · 17 runs · CN · Adult · 2022 · 2.05 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 102 sample values (collection date, country, health condition, health condition detail, latitude, longitude) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC12911420 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 15 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 17 | 100% | ||||
| country | 17 | 100% | 17 | |||
| health_condition | 17 | 100% | 17 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 17 | 100% | 17 | |||
| health_condition_detail | 17 | 100% | 17 | |||
| latitude | 17 | 100% | 17 | |||
| longitude | 17 | 100% | 17 |
- Comprehensive profiling of antibiotic resistance, virulence genes, and mobile genetic elements in the gut microbiome of Tibetan antelopes. 2026 PMID 41432144 PMC12911420 own_data
Archive description
Gut microbiota acts as an important complementary role in human health and is shaped by diverse factors including ethnicity, dietary pattern, and surrounding environmental factors. However, the effect of high-altitude environments on the human gut microbiota is rarely investigated. Herein, we characterized the gut microbiota of 30 and 18 healthy individuals living in sea level and high-altitude areas, respectively, using deep whole-metagenome shotgun sequencing of their fecal samples. The results in this pilot study provided pieces for understanding the underlying mechanisms of high-altitude geographic adaptation of the human gut microbiome.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_maternal_only”
- body site study.title · “Fecal metagenome dataset of”
- body site study.description · “Gut microbiota acts as”
- life stage external_curation.infant_catalog · “infant triage reason_code age_maternal_only”
- life stage study.title · “of 48 healthy women”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA14491526 | collection_date | 2021 | R1 | 0.90 | biosample.attribute:collection_date | 2021 |
| SAMEA14491526 | country | CN | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | China |
| SAMEA14491526 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:description | gut metagenome of healthy female |
| SAMEA14491526 | health_condition_detail | gut metagenome of healthy female | R1 | 0.85 | biosample.attribute:description | gut metagenome of healthy female |
| SAMEA14491526 | latitude | 31.0000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 31 92 |
| SAMEA14491526 | longitude | 92.0000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 31 92 |
Sequencing
17 runs over 17 samples · mean 1.99 Gbp per run (median 2.05 Gbp, total 33.81 Gbp; 17 runs with a base count) · layout PAIRED 17 · platform ILLUMINA 17 · models Illumina NovaSeq 6000 (17) · 88% of runs with a Sandpiper profile · first public 2022-06-01
Authors (17)
Liu J first · Ni HB · Yu MY · Qin SY · Elsheikha HM · Peng P · Guo L · Xie LH · Liang HR · Lei CC · Xu Y · Tang Y · Yu HL · Qin Y · Sun HC · Zhang XX · Qiu B last
Downloads
PRJEB53209.csv.gz (1.3 KB) · parquet (70.0 KB) — all 17 samples, every field with route and confidence · PRJEB53209_determinations.csv.gz (1.1 KB) — 102 evidence rows