Gut microbiome in HLA-B27 anterior uveitis, Switzerland
41 gut metagenome samples from Switzerland in a case-control study comparing patients with HLA-B27-associated anterior uveitis to HLA-B27-negative and HLA-B27-positive healthy controls. machine-written summary
41 samples · 41 runs · CH · Adult · 2025 · 10.76 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 276 sample values (age, bmi, collection date, country, health condition, health condition detail, sex) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 82 sample values (antibiotic exposure, subject id) · PMC11077820 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 35 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 41 | 100% | ||||
| country | 41 | 100% | 41 | |||
| health_condition | 41 | 100% | 41 | |||
| subject_id | 41 | 100% | 41 | |||
| age_at_collection_days | 41 | 100% | 41 | |||
| antibiotic_exposure | 41 | 100% | 41 | |||
| bmi | 41 | 100% | 41 | |||
| health_condition_detail | 41 | 100% | 41 | |||
| sex | 41 | 100% | 41 | |||
| collection_date | 30 | 73% | 30 |
- The gut microbiome and HLA-B27-associated anterior uveitis: a case-control study. 2024 PMID 38715051 PMC11077820 own_data
Archive description
The human gut microbiome is a complex ecosystem and refers to the combined genetic material of microorganisms in the gut. Dysbiotic conditions can favor invasion and growth of pathogenic species and can disrupt immune homeostasis, thus potentially induce diseases. In this study, we investigated compositional and functional alterations of the gut microbiome in patients with anterior (AAU) by comparing their microbiome with healthy HLA B27 negative controls.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by sonnet_x2 with confidence 0.75. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.description · “human gut microbiome is a complex ecosystem”
- life stage sample.attr.age · “23 (n=34/41)”
- life stage sample.attr.age · “62 (n=7/41)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA120325584 | age_at_collection_days | 8400.8 | R1 | 0.70 | sample.attr.age | 23 |
| SAMEA120325584 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | use of systemic antibiotics within the last 3 months |
| SAMEA120325584 | bmi | 30.5 | R1 | 0.90 | sample.attr.bmi | 30.5 |
| SAMEA120325588 | collection_date | 1997-07-14 | R1 | 0.90 | biosample.attribute:collection_date | 1997-07-14 |
| SAMEA120325584 | country | CH | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Switzerland |
| SAMEA120325584 | health_condition | autoimmune_inflammatory | R1 | 0.85 | biosample.attribute:description | description: patient |
| SAMEA120325584 | health_condition_detail | patient | R1 | 0.85 | biosample.attribute:description | description: patient |
| SAMEA120325584 | sex | female | R1 | 0.90 | sample.attr.sex | w |
| SAMEA120325584 | subject_id | SAMEA120325584 | R3 | 0.75 | design.one_sample_per_subject:fulltext | a cross-sectional case-control study was performed. It is based on the collection of stool samples from 47 study participants. |
Sequencing
41 runs over 41 samples · mean 10.32 Gbp per run (median 10.76 Gbp, total 422.96 Gbp; 41 runs with a base count) · layout PAIRED 41 · platform ILLUMINA 41 · models Illumina NovaSeq 6000 (41) · 85% of runs with a Sandpiper profile · first public 2025-10-18
Authors (8)
Morandi SC first · Herzog EL · Munk M · Kreuzer M · Largiadèr CR · Wolf S · Zinkernagel M · Zysset-Burri DC last
Downloads
PRJEB55787.csv.gz (2.6 KB) · parquet (72.5 KB) — all 41 samples, every field with route and confidence · PRJEB55787_determinations.csv.gz (4.0 KB) — 358 evidence rows