Diet intervention in Parkinson's patients and spouses, Germany

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intervention — arms not resolved

Controlled / prescribed diet or feeding regimen Prebiotic / dietary fibre supplement design single_arm_before_after · population neurological_psychiatric · 4-week high-fibre diet with lactulose prebiotic

“4-week diet rich in dietary fibre, including intake of the prebiotic Lactulose” — abstract:40180909 (study level; per-sample arms are in the intervention column below)

longitudinalhouseholdspartners / couples

20 of 22 people sampled more than once (42 samples; median 2, up to 3 per person) · follow-up median 28 d (max 3 mo) · median interval between samples 28 d (time from collection dates). Schedule stated by the source: “faecal samples at baseline and 4 weeks after diet” (time origin: baseline); stated follow-up 28 d.

Each row is one person (20 shown); dots are samples at days since that person's first sample; rows of one family are adjacent and coloured by role (mother, father, child, twin).

11 couples: Parkinson's patient + healthy spouse control, sampled before/after a 4-week fibre diet · 11 families with 22 sampled people.

partner · circles are people (pale = no sequenced sample), arrows run donor → recipient and parent → child, curved lines join twins, partners and siblings, squares are shared settings or families without recorded roles. Shown: 11 linked groups from explicit relations. 22 people in the project overall.

How longitudinal and relatedness information is derived

Genera, mean relative abundance over 41 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

• A prebiotic dietary pilot intervention restores faecal metabolites and may be neuroprotective in Parkinson's Disease. 2025 PMID 40180909 PMC11968880 own_data