Gut microbiome in social anxiety disorder, Ireland (case-control)
Case-control study of 284 faecal samples from adults in Ireland, comparing gut microbiome composition and function between social anxiety disorder patients and healthy controls. machine-written summary
284 samples · 284 runs · IE · Age unknown · 2023 · 0.48 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,412 sample values (collection date, country, health condition, health condition detail, subject id) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 284 sample values (antibiotic exposure) · PMC10027687 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
71 of 71 people sampled more than once (284 samples; median 4, up to 4 per person).
Genera, mean relative abundance over 256 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 284 | 100% | ||||
| country | 284 | 100% | 284 | |||
| health_condition | 280 | 99% | 280 | |||
| subject_id | 284 | 100% | 284 | |||
| antibiotic_exposure | 284 | 100% | 284 | |||
| collection_date | 284 | 100% | 284 | |||
| health_condition_detail | 280 | 99% | 280 |
- The gut microbiome in social anxiety disorder: evidence of altered composition and function. 2023 PMID 36941248 PMC10027687 own_data
Archive description
The microbiome-gut-brain axis plays a role in anxiety, the stress response and social development, and is of growing interest in neuropsychiatric conditions. The gut microbiome shows compositional alterations in a variety of psychiatric disorders including depression, generalised anxiety disorder (GAD), autism spectrum disorder (ASD) and schizophrenia but studies investigating the gut microbiome in social anxiety disorder (SAD) are very limited. Using whole-genome shotgun analysis of 49 faecal samples (31 cases and 18 sex- and age-matched controls), we analysed compositional and functional differences in the gut microbiome of patients with SAD in comparison to healthy controls. Overall microbiome composition, as measured by beta-diversity, was found to be different between the SAD and control groups and several taxonomic differences were seen at a genus- and species-level. The relative abundance of the genera Anaeromassillibacillus and Gordonibacter were elevated in SAD, while Parasuterella was enriched in healthy controls. At a species-level, Anaeromassilibacillus sp An250 was found to be more abundant in SAD patients while Parasutterella excrementihominis was higher in controls. No differences were seen in alpha diversity. In relation to functional differences, the gut metabolic module ‘aspartate degradation I’ was elevated in SAD patients. In conclusion, the gut microbiome of patients with SAD differs in composition and function to that of healthy controls. Larger, longitudinal studies are warranted to validate these preliminary results and explore the clinical implications of these microbiome changes.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.80. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.description · “whole-genome shotgun analysis of 49 faecal samples”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA112306995 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | use of probiotics, prebiotics or antibiotics in the previous 4 weeks |
| SAMEA112306995 | collection_date | 2019 | R1 | 0.90 | biosample.attribute:collection_date | 2019 |
| SAMEA112306995 | country | IE | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Ireland |
| SAMEA112306995 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:description | CONT |
| SAMEA112306995 | health_condition_detail | CONT | R1 | 0.85 | biosample.attribute:description | CONT |
| SAMEA112306995 | subject_id | 76002 | R1 | 0.85 | biosample.attribute:title | 76002 |
Sequencing
284 runs over 284 samples · mean 0.53 Gbp per run (median 0.48 Gbp, total 149.38 Gbp; 284 runs with a base count) · layout PAIRED 284 · platform ILLUMINA 284 · models NextSeq 550 (284) · 90% of runs with a Sandpiper profile · first public 2023-01-20
Authors (14)
Butler MI first · Bastiaanssen TFS · Long-Smith C · Morkl S · Berding K · Ritz NL · Strain C · Patangia D · Patel S · Stanton C · O'Mahony SM · Cryan JF · Clarke G · Dinan TG last
Downloads
PRJEB58864.csv.gz (6.6 KB) · parquet (79.0 KB) — all 284 samples, every field with route and confidence · PRJEB58864_determinations.csv.gz (9.6 KB) — 1,696 evidence rows