Oat vs spelt bran fibre intervention in healthy women, Austria
40 samples from a cross-over intervention study in healthy, normal-weight adult women in Austria, comparing short-term oat bran and spelt bran fibre-rich flake mixes on gut microbiota, intestinal barrier markers, and health parameters. machine-written summary
40 samples · 40 runs · AT · Adult · 2023 · 6.55 Gbp / sample
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what each source gave
| ✓ Sequence archive | 200 sample values (collection date, country, intervention, subject id, timepoint) |
| ✓ Abstract / description | 80 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Controlled / prescribed diet or feeding regimen Prebiotic / dietary fibre supplement design crossover · population healthy_control · Oat bran vs spelt bran fiber-rich flake mixes, one-week each, crossover
“fiber rich oat bran rich and spelt bran rich flake mixes” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal
10 of 10 people sampled more than once (40 samples; median 4, up to 4 per person) · follow-up median 7 d (max 7 d) · median interval between samples 7 d (time from timepoint labels). Schedule stated by the source: “stool/blood at baseline and end of each one-week intervention (oat and spelt bran, cross-over)” (time origin: intervention_start).
Each row is one person (10 shown); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 38 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 40 | 100% | ||||
| country | 40 | 100% | 40 | |||
| health_condition | 40 | 100% | 40 | |||
| subject_id | 40 | 100% | 40 | |||
| collection_date | 40 | 100% | 40 | |||
| health_condition_detail | 40 | 100% | 40 | |||
| intervention | 40 | 100% | 40 | |||
| timepoint_label | 40 | 100% | 40 |
Archive description
Diets low in dietary fiber have repeatedly been shown to be associated with higher risks for various non-communicable chronic diseases (NCCDs). Here, we assessed in a cross-over designed study if fiber rich oat bran rich and spelt bran rich flake mixes (~11.7g total fiber), respectively, are suitable to increase general fiber intake in healthy women and if this enhancement of dietary fiber intake impacts intestinal microbiota composition, markers of intestinal barrier function, and general health parameters. Dietary intake was determined and blood and stool samples were collected along with a general health assessment before and at the end of each one-week intervention from 10 female, normal weight participants (aged 31.9 ± 2.6 years). The intake of the eitherboth flake mixes was associated with a significant increase in dietary fiber intake during the interventions while overall dietary pattern and macronutrient intake remained almost unchanged. After the spelt bran intervention only blood pressure was significantly lower whereas after the intake of the oat bran rich flakes LDL- and total cholesterol levels as well as alanine transaminase (ALT) and aspartate transaminase (AST) activities in blood were also significantly lower. The incorporation of the oat bran flake mix in the diet resulted in a significant decrease of bacterial endotoxin in blood but no change in intestinal microbiota composition whereas effects alike were not found after the intake of spelt bran. Taken together, results of our study suggest that fiber rich flake mixes may be a suitable measure to increase overall dietary fiber intake and thereby improve general health but that health effects and mechanisms underlying may differ between different dietary fibers.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.88. Assay shotgun_dna.
- host study.description · “blood and stool samples were collected”
- body site run.scientific_name · “human feces metagenome”
- life stage study.description · “aged 31.9 ± 2.6 years”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA113609446 | collection_date | 2019 | R1 | 0.90 | biosample.attribute:collection_date | 2019 |
| SAMEA113609446 | country | AT | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Austria |
| SAMEA113609446 | health_condition | healthy_control | R4 | 0.50 | study.title | healthy women |
| SAMEA113609446 | health_condition_detail | healthy women receiving dietary fiber intervention (oat bran or spelt bran) | R4 | 0.50 | study.title | healthy women |
| SAMEA113609446 | intervention | no_intervention | R1 | 0.70 | sample.name_rule:description | ID01, baseline, Oat, P1 |
| SAMEA113609446 | subject_id | 01 | R1 | 0.70 | sample.name_rule:description | ID01, baseline, Oat, P1 |
| SAMEA113609446 | timepoint_label | baseline | R1 | 0.70 | sample.name_rule:description | ID01, baseline, Oat, P1 |
Sequencing
40 runs over 40 samples · mean 6.83 Gbp per run (median 6.55 Gbp, total 273.20 Gbp; 40 runs with a base count) · layout PAIRED 40 · platform ILLUMINA 40 · models NextSeq 500 (40) · 95% of runs with a Sandpiper profile · first public 2023-11-09
Authors (0)
No author record.
Downloads
PRJEB63222.csv.gz (1.9 KB) · parquet (71.1 KB) — all 40 samples, every field with route and confidence · PRJEB63222_determinations.csv.gz (3.0 KB) — 280 evidence rows