Gut microbiome in malnourished infants, Bangladesh
Shotgun metagenomic study of 1519 human faecal samples from infants with severe acute malnutrition following acute nutritional resuscitation, evaluating a microbiota-directed therapeutic food in Bangladesh. machine-written summary
1,519 samples · 1,519 runs · BD · Infant / toddler · 2025 · 2.14 Gbp / sample · cohort A microbiome-directed therapeutic food for childre
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 3,798 sample values (country, subject id, timepoint) |
| ✓ Abstract / description | 3,038 sample values (health condition detail, location region) |
| ✓ Full text | 3,038 sample values (antibiotic exposure, health condition) · PMC11572952 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Controlled / prescribed diet or feeding regimen design randomized_controlled_trial · population malnutrition · Microbiota-Directed Complementary Food (MDCF-2) vs ready-to-use supplementary food, 3 months
“Microbiota-Directed Complementary Food (MDCF) versus a ready to use supplementary food” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
140 of 140 people sampled more than once (1,519 samples; median 11, up to 13 per person). Schedule stated by the source: “unclear; stated only as serially collected fecal samples during a 3-month intervention trial, exact days not given in dossier” (time origin: intervention start); stated follow-up 3 mo.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 1,519 | 100% | ||||
| country | 1,519 | 100% | 1,519 | |||
| health_condition | 1,519 | 100% | 1,519 | |||
| subject_id | 1,519 | 100% | 1,519 | |||
| antibiotic_exposure | 1,519 | 100% | 1,519 | |||
| detailed_location | 1,519 | 100% | ||||
| health_condition_detail | 1,519 | 100% | 1,519 | |||
| location_region | 1,519 | 100% | 1,519 | |||
| timepoint_label | 760 | 50% | 760 |
- A microbiome-directed therapeutic food for children recovering from severe acute malnutrition. 2024 PMID 39356745 PMC11572952 own_data
Archive description
Complete anthropometric recovery from severe acute malnutrition using standard therapeutic inventions is rare rather, children treated for severe acute malnutrition (SAM) often are left in a state of moderate acute malnutrition (MAM). Here we conduct a randomized controlled clinical trial to investigate the efficacy of a standard dietary treatment for SAM in 12-18-month-old Bangladeshi children followed by a 3-month-long treatment with a Microbiota-Directed Complementary Food (MDCF) versus a ready to use supplementary food.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler by curator_audit with confidence 0.40. Assay shotgun_dna.
- host runs.scientific_name · “human gut metagenome”
- host study_title · “severely malnourished children evaluated following acute nutritional resuscitation”
- body site runs.scientific_name · “human gut metagenome”
- body site study_title · “severely malnourished children evaluated following acute nutritional resuscitation”
- life stage study.description · “12-18-month-old Bangladeshi children”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA115576519 | antibiotic_exposure | yes | R3 | 0.70 | paper.fulltext.methods | administration of antibiotics, micronutrient supplementation |
| SAMEA115576519 | country | BD | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Bangladesh |
| SAMEA115576519 | health_condition | malnutrition | R3 | 0.70 | paper.fulltext.methods | children with post-SAM MAM |
| SAMEA115576519 | health_condition_detail | severe acute malnutrition (SAM), children after nutritional resuscitation | R4 | 0.50 | archive.study_title | A microbiota-directed therapeutic food for severely malnourished children |
| SAMEA115576519 | location_region | Bangladesh | R4 | 0.45 | ena.study_description | 12-18-month-old Bangladeshi children |
| SAMEA115576519 | subject_id | S01 | R1 | 0.70 | sample.name_rule:TITLE | S01C8881101_metagenome |
| SAMEA115711601 | subject_id | pSM121 | R1 | 0.70 | sample.name_rule:alias | pSM1211101 |
| SAMEA115711601 | timepoint_label | 1101 | R1 | 0.60 | sample.name_rule:alias | pSM1211101 |
Sequencing
1,519 runs over 1,519 samples · mean 2.11 Gbp per run (median 2.14 Gbp, total 3,207.18 Gbp; 1,519 runs with a base count) · layout PAIRED 1,519 · platform ILLUMINA 1,519 · models unspecified (1,519) · 99% of runs with a Sandpiper profile · first public 2025-06-26
Authors (0)
No author record.
Downloads
PRJEB63587.csv.gz (33.0 KB) · parquet (105.2 KB) — all 1,519 samples, every field with route and confidence · PRJEB63587_determinations.csv.gz (55.7 KB) — 9,874 evidence rows