Gut metagenome in FMT trial for Parkinson's disease, Finland
416 fecal metagenome samples from a Finnish trial of fecal microbiota transplantation in Parkinson's disease patients; intervention arms received transplants from two donors, with a placebo arm, monitored over time. machine-written summary
416 samples · 416 runs · FI · Adult · 2024 · 5.18 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,592 sample values (collection date, country, subject id, timepoint) |
| ✓ Abstract / description | 832 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation design randomized_controlled_trial · population neurological_psychiatric · FMT from two donors vs placebo in Parkinson's disease, 15 placebo and 15+15 FMT
“15 placebo and 15+15 fecal transplantations from two donors” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolvedFMT donor → recipient — not resolved
47 of 99 people sampled more than once (361 samples; median 8, up to 8 per person).
Parkinson FMT RCT: 2 donor stool samples (HM, PA); 15+15 recipients and 15 placebo; donor per recipient arm not given per sample.
Genera, mean relative abundance over 373 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 416 | 100% | ||||
| country | 416 | 100% | 416 | |||
| health_condition | 416 | 100% | 416 | |||
| subject_id | 413 | 99% | 413 | |||
| collection_date | 416 | 100% | 416 | |||
| health_condition_detail | 416 | 100% | 416 | |||
| timepoint_label | 347 | 83% | 347 |
Archive description
Study off 45 Parkinson's patients with 15 placebo and 15+15 fecal transplantations from two donors monitored over time using shotgun sequencing of gut metagenome.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Fecal microbiota transplantation in”
- body site study.description · “placebo and 15+15 fecal transplantations from two”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA115136727 | collection_date | 2021 | R1 | 0.90 | biosample.attribute:collection_date | 2021 |
| SAMEA115136727 | country | FI | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Finland |
| SAMEA115136727 | health_condition | neurological_psychiatric | R4 | 0.50 | study.description | Parkinson's patients |
| SAMEA115136727 | health_condition_detail | Parkinson's disease | R4 | 0.50 | study.description | Parkinson's patients |
| SAMEA115136727 | subject_id | 1.001 | R1 | 0.70 | sample.name_rule:alias | X1.001_DNA_PRO1_CP05139 |
| SAMEA115136727 | timepoint_label | PRO1 | R1 | 0.70 | sample.name_rule:alias | X1.001_DNA_PRO1_CP05139 |
Sequencing
416 runs over 416 samples · mean 9.06 Gbp per run (median 5.18 Gbp, total 3,768.00 Gbp; 416 runs with a base count) · layout PAIRED 416 · platform ILLUMINA 416 · models Illumina NovaSeq 6000 (416) · 90% of runs with a Sandpiper profile · first public 2024-08-01
Authors (0)
No author record.
Downloads
PRJEB68317.csv.gz (10.4 KB) · parquet (83.8 KB) — all 416 samples, every field with route and confidence · PRJEB68317_determinations.csv.gz (16.7 KB) — 2,424 evidence rows