Personalized diet vs general advice RCT, USA gut microbiome
931 gut metagenome samples from a USA-based randomised controlled trial comparing a personalised dietary programme to standard USDA-based dietary advice, assessing effects on cardiometabolic health (LDL-C, triglycerides). machine-written summary
931 samples · 931 runs · US · Age unknown · 2024 · 5.15 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 931 sample values (country) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 931 sample values (antibiotic exposure) · PMC11271409 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Controlled / prescribed diet or feeding regimen design randomized_controlled_trial · population cardiometabolic_other · Personalised dietary programme (18-week app-based) vs standard USDA dietary advice
“personalised dietary programme (intervention) in comparison general advice” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
Schedule stated by the source: “Samples collected at baseline, week 12, and week 18 of the 18-week intervention (per figure legend describing relative abundance at baseline, week 12 and week 18).” (time origin: intervention_start); stated follow-up 4 mo.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 931 | 100% | 931 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 931 | 100% | 931 |
- Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. 2024 PMID 38714898 PMC11271409 own_data
Archive description
Large variability exists in people's responses to foods. A randomised controlled trial was conducted to investigate the impact of a personalised dietary programme (intervention) in comparison general advice (control) on cardiometabolic health. The personalised dietary programme used food characteristics, individual postprandial glucose and triglyceride responses to foods, microbiomes, and health history, to produce personalised food scores in an 18-week app-based programme. The control group received standard care dietary advice (USDA Guidelines for Americans, 2020-2025) using online resources, check-ins, video lessons and a leaflet. Primary outcomes were serum low-density lipoprotein cholesterol (LDL-C) and triglyceride concentrations at baseline and 18-weeks. ClinicalTrials.gov identifier: NCT05273268.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.57. Assay shotgun_dna.
- host study.description · “randomised controlled trial was conducted”
- body site run.scientific_name · “gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA115468749 | antibiotic_exposure | no | R3 | 0.70 | paper.body.methods_results | were taking the following daily medications: immunosuppressants, corticosteroids or antibiotics in the last 3 months, not including inhalers |
| SAMEA115468749 | country | US | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | USA |
Sequencing
931 runs over 931 samples · mean 5.51 Gbp per run (median 5.15 Gbp, total 5,133.13 Gbp; 931 runs with a base count) · layout PAIRED 931 · platform ILLUMINA 931 · models unspecified (931) · 0% of runs with a Sandpiper profile · first public 2024-04-18
Authors (0)
No author record.
Help complete this project
3 of the 4 core fields are below 50% coverage: age_category, health_condition, subject_id. Share metadata
Downloads
PRJEB74042.csv.gz (20.6 KB) · parquet (101.8 KB) — all 931 samples, every field with route and confidence · PRJEB74042_determinations.csv.gz (7.1 KB) — 1,862 evidence rows