Gut microbiome in glaucoma patients, Switzerland
Case-control study of 32 stool samples from Switzerland comparing the gut microbiome of glaucoma patients and healthy individuals using whole-metagenome shotgun sequencing. machine-written summary
1 samples · 32 runs · CH · Age unknown · 2025 · 8.08 Gbp / sample · cohort Uncovering the relationship between the human ocul
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 3 sample values (collection date, country, sex) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC13069832 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 1 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 1 | 100% | 1 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 1 | 100% | 1 | |||
| sex | 1 | 100% | 1 |
- Uncovering the relationship between the human ocular surface microbiome and gut microbiome. 2026 PMID 41781852 PMC13069832 unsure
Archive description
Although glaucoma is a leading cause of irreversible blindness worldwide, its pathogenesis is incompletely understood and the intraocular pressure (IOP) is the only modifiable risk factor to target the disease. Several associations between the gut microbiome and glaucoma including the IOP have been suggested. There is growing evidence that the gut microbiome may also play a role in ocular diseases such as glaucoma. In this study, we aimed to find characteristic features of the gut microbiome in patients with glaucoma. By whole-metagenome shotgun sequencing of 32 stool samples, we identified the diversity of the gut microbiome in healthy induviduals and in glaucoma patients.This study may help to design new therapeutic approaches to target glaucoma and other associated diseases.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.78. Assay shotgun_dna.
- host run.scientific_name · “Homo sapiens”
- body site study.description · “32 stool samples”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA115489487 | collection_date | 2023-03-15 | R1 | 0.90 | biosample.attribute:collection_date | 2023-03-15 |
| SAMEA115489487 | country | CH | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Switzerland |
| SAMEA115489487 | sex | male | R1 | 0.90 | sample.attr.sex | m |
Sequencing
32 runs over 1 samples · mean 8.68 Gbp per run (median 8.08 Gbp, total 277.88 Gbp; 32 runs with a base count) · layout PAIRED 32 · platform ILLUMINA 32 · models Illumina NovaSeq 6000 (32) · 97% of runs with a Sandpiper profile · first public 2025-08-26 – 2025-09-13
Authors (6)
Eldridge N first · Spörri L · Kreuzer M · Haldimann G · Zinkernagel MS · Zysset-Burri DC last
Downloads
PRJEB74773.csv.gz (857 B) · parquet (68.6 KB) — all 1 samples, every field with route and confidence · PRJEB74773_determinations.csv.gz (383 B) — 3 evidence rows