Repeated FMT vs placebo in HIV-infected adults, Spain
84 gut metagenome samples from Spain, from HIV-infected adults on antiretroviral therapy, in a double-blind, placebo-controlled pilot trial of repeated low-dose fecal microbiota transplantation. machine-written summary
84 samples · 84 runs · ES · Adult · 2024 · 0.43 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 948 sample values (age, collection date, country, health condition, health condition detail, intervention, intervention detail, latitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 84 sample values (location site) · PMC11494993 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
21 people have samples in more than one arm.
Faecal microbiota transplantation design randomized_controlled_trial · population other_infection · Weekly oral FMT capsules vs placebo for 8 weeks
“weekly fecal microbiota capsules or placebo” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinalFMT donor → recipient — not resolved
22 of 28 people sampled more than once (78 samples; median 4, up to 4 per person) · follow-up median 6 mo (max 6 mo) · median interval between samples 49 d (time from visit codes mapped to the stated schedule).
Each row is one person (14 shown of 22); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 79 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 84 | 100% | ||||
| country | 84 | 100% | 84 | |||
| health_condition | 84 | 100% | 84 | |||
| subject_id | 84 | 100% | 84 | |||
| age_at_collection_days | 84 | 100% | 84 | |||
| collection_date | 84 | 100% | 84 | |||
| detailed_location | 84 | 100% | ||||
| health_condition_detail | 84 | 100% | 84 | |||
| intervention | 84 | 100% | 84 | |||
| latitude | 84 | 100% | 84 | |||
| location_site | 84 | 100% | 84 | |||
| longitude | 84 | 100% | 84 | |||
| timepoint_label | 84 | 100% | 84 | |||
| sex | 81 | 96% | 81 | |||
| intervention_detail | 27 | 32% | 27 |
- Fecal microbiota transplantation in HIV: A pilot placebo-controlled study. 2021 PMID 33602945 PMC7892558 own_data
- Fecal microbiota transplantation alters the proteomic landscape of inflammation in HIV: identifying bacterial drivers. 2024 PMID 39438902 PMC11494993 own_data
Archive description
Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio < 1 randomized to either weekly fecal microbiota capsules or placebo for 8 weeks. Stool donors were rationally selected based on their microbiota signatures. We report that fecal microbiota transplantation (FMT) is safe, not related to severe adverse events, and attenuates HIV-associated dysbiosis. FMT elicits changes in gut microbiota structure, including significant increases in alpha diversity, and a mild and transient engraftment of donor’s microbiota during the treatment period. FMT also modulates systemic inflammation. Gut microbiota manipulation using a non-invasive and safe strategy of FMT delivery is feasible and deserves further investigation. Trial number: NCT03008941.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “REpeated Fecal microbiota REStoration in”
- body site study.description · “to either weekly fecal microbiota capsules or”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA115956018 | age_at_collection_days | 19358.2 | R1 | 0.70 | sample.attr.host_age | 53 |
| SAMEA115956018 | collection_date | 2017 | R1 | 0.90 | biosample.attribute:collection_date | 2017 |
| SAMEA115956018 | country | ES | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Spain |
| SAMEA115956018 | health_condition | other_infection | R1 | 0.85 | biosample_attr | HIV infection |
| SAMEA115956018 | health_condition_detail | HIV infection | R1 | 0.90 | sample.attr.host_disease_status | HIV infection |
| SAMEA115956018 | intervention | no_intervention | R1 | 0.80 | biosample.attribute:timepoint | timepoint: 0 |
| SAMEA115956019 | intervention | fmt | R1 | 0.85 | biosample.attribute:type_of_perturbation_e_g_chemical_administration_physical_disturbance_etc_coupled_with_time_that_perturbation_occurred_can_include_multiple_perturbation_types | type_of_perturbation_e_g_chemical_administration_physical_disturbance_etc_coupled_with_time_that_perturbation_occurred_can_include_multiple_perturbation_types: fecal microbiota transplant |
| SAMEA115956018 | intervention_detail | timepoint = 0 (before intervention start) | R1 | 0.80 | biosample.attribute:timepoint | timepoint: 0 |
| SAMEA115956018 | latitude | 40.4200 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 40,42 -3,70 |
| SAMEA115956018 | location_site | Hospital Universitario Ramón y Cajal | R3 | 0.70 | paper.fulltext.methods | HIV unit of Hospital Universitario Ramón y Cajal in Madrid |
| SAMEA115956018 | longitude | -3.7000 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 40,42 -3,70 |
| SAMEA115956018 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
| SAMEA115956018 | subject_id | P01 | R1 | 0.85 | sample.attr.host_subject_id | P01 |
| SAMEA115956018 | timepoint_label | 0 | R1 | 0.85 | sample.attr.timepoint | 0 |
Sequencing
84 runs over 84 samples · mean 0.41 Gbp per run (median 0.43 Gbp, total 34.68 Gbp; 84 runs with a base count) · layout PAIRED 84 · platform ILLUMINA 84 · models Illumina MiSeq (84) · 94% of runs with a Sandpiper profile · first public 2024-08-27
Authors (29)
Serrano-Villar S first · Talavera-Rodríguez A · Gosalbes MJ · Madrid N · Pérez-Molina JA · Elliott RJ · Navia B · Lanza VF · Vallejo A · Osman M · Dronda F · Budree S · Zamora J · Gutiérrez C · Manzano M · Vivancos MJ · Ron R · Martínez-Sanz J · Herrera S · Ansa U · Moya A · Moreno S last · Díaz-García C first · Moreno E · Martín-Fernández L · González-Bodí S · Martín-Pedraza L · Luna L · Huerta-Cepas J
Downloads
PRJEB75958.csv.gz (3.4 KB) · parquet (75.2 KB) — all 84 samples, every field with route and confidence · PRJEB75958_determinations.csv.gz (6.8 KB) — 1,032 evidence rows