Gut microbiome in alcohol-related liver disease, Denmark
Cross-sectional study of 369 gut metagenome samples from a Danish cohort of adults with alcohol-related liver disease, examining links between gut microbial bile acid metabolism and liver fibrosis severity. machine-written summary
369 samples · 1,045 runs · DK · Adult · 2024 · 8.38 Gbp / sample · cohort Alcohol-related liver disease disrupts bile acid h
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,050 sample values (country, health condition, health condition detail) |
| ✓ Abstract / description | 738 sample values (collection date, health condition detail, subject id) |
| ○ Full text | read; no usable statement or table · PMC13233754 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 361 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 369 | 100% | ||||
| country | 350 | 95% | 350 | |||
| health_condition | 350 | 95% | 350 | |||
| subject_id | 350 | 95% | 350 | |||
| collection_date | 369 | 100% | 369 | |||
| health_condition_detail | 369 | 100% | 350 | 19 |
- Alcohol-related liver disease disrupts bile acid homeostasis and gut microbial bile acid metabolism. 2026 PMID 41935631 PMC13233754 unsure
Archive description
This is a prospective, single-center, biopsy-controlled, cross-sectional study, which covers the full range of alcohol-related liver diseases. Inclusion criteria comprised individuals aged 18-75 years with prior or current chronic alcohol overuse, which was defined as more than 24 g/d for women and more than 36 g/d for men for over a year, and informed consent to a liver biopsy. Patients were recruited between 2013 and 2018.
How this project entered the registry
Classified as human gut / stool mixed assays of adult by sonnet_x2 with confidence 0.75. Assay mixed.
- host run.scientific_name · “human gut metagenome”
- body site study.title · “gut microbiome in patients with alcohol-related liver disease”
- life stage study.description · “individuals aged 18-75 years with prior or current chronic alcohol overuse”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA115779539 | collection_date | 2013/2018 | R4 | 0.45 | ena.study_description | Patients were recruited between 2013 and 2018 |
| SAMEA115779539 | country | DK | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Denmark |
| SAMEA115779539 | health_condition | liver_disease | R1 | 0.70 | sample.name_rule:alias | GALA-ALD_UAMTS |
| SAMEA115779539 | health_condition_detail | patient recruited for chronic alcohol overuse + liver biopsy per study inclusion criteria (full spectrum of alcohol-rela | R1 | 0.70 | sample.name_rule:alias | GALA-ALD_UAMTS |
| SAMEA117993267 | health_condition_detail | mixed_case_control: alcohol-related liver disease patients vs healthy controls | R4 | 0.40 | study.description | individuals aged 18-75 years with prior or current chronic alcohol overuse |
| SAMEA115779539 | subject_id | SAMEA115779539 | R4 | 0.65 | design.one_sample_per_subject:description | This is a prospective, single-center, biopsy-controlled, cross-sectional study, which covers the full range of alcohol-related liver diseases. |
Sequencing
1,045 runs over 369 samples · mean 2.83 Gbp per run (median 3.08 Gbp, total 2,955.12 Gbp; 1,045 runs with a base count) · layout PAIRED 704, SINGLE 341 · platform ILLUMINA 1,045 · models Illumina HiSeq 4000 (682), Illumina NovaSeq 6000 (316), NextSeq 500 (47) · 93% of runs with a Sandpiper profile · first public 2024-11-12 – 2025-04-14
Authors (25)
Keller MI first · de Zawadzki A · Thiele M · Suvitaival T · Sulek K · Kuhn M · Schudoma C · Podlesny D · Nishijima S · Fullam A · Kim CY · Niu L · Wretlind A · Hansen JK · Israelsen M · Johansen S · Akanni W · Hazenbrink D · Juel HB · Mann M · Hansen T · Krag A · Bork P · Legido-Quigley C · GALAXY & MicrobLiver consortia last
Downloads
PRJEB76661.csv.gz (10.2 KB) · parquet (85.4 KB) — all 369 samples, every field with route and confidence · PRJEB76661_determinations.csv.gz (14.0 KB) — 1,788 evidence rows