Gut microbiome & helminth treatment response, Mozambique
223 gut microbiome samples from Mozambique, from hosts infected or not with soil-transmitted helminths, examining how microbiome variation relates to anthelmintic treatment response; case-control design. machine-written summary
223 samples · 223 runs · MZ · Age unknown · 2025 · 2.93 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 669 sample values (collection date, country, subject id) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 139 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 223 | 100% | 223 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 223 | 100% | 223 | |||
| collection_date | 223 | 100% | 223 |
Archive description
Soil-transmitted helminths (STH) infect over a billion people worldwide, causing significant disease and sustaining poverty. As gastrointestinal pathogens, STH directly impact and are impacted by interactions with the microbial community of the host. These interactions likely play a role in the establishment, persistence, and infection load of STHs. Importantly, these interactions may play a role in the response of STH to drug treatment. Although there are an increasing number of studies focused on characterising human microbiomes, there is a significant underrepresentation of microbiomes from Africa relative to Western countries. Therefore, no existing datasets are suitable to address questions relevant to STH and host-microbiome interactions in STH-endemic countries. These data have been generated to assess the microbiome composition of human hosts infected or not with soil-transmitted helminths, and to understand if variation in the microbiome impacts treatment responses to anthelmintic treatment.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.55. Assay shotgun_dna.
- host study.description · “microbiome composition of human hosts infected”
- body site study.description · “gastrointestinal pathogens, STH directly impact”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA116001794 | collection_date | 2018 | R1 | 0.90 | biosample.attribute:collection_date | 2018 |
| SAMEA116001794 | country | MZ | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Mozambique |
| SAMEA116001794 | subject_id | 7860STDY15122223 | R1 | 0.85 | sample.attr.subject_id | 7860STDY15122223 |
Sequencing
223 runs over 223 samples · mean 2.93 Gbp per run (median 2.93 Gbp, total 653.66 Gbp; 223 runs with a base count) · layout PAIRED 223 · platform ILLUMINA 223 · models Illumina NovaSeq 6000 (223) · 95% of runs with a Sandpiper profile · first public 2025-10-18
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJEB79832.csv.gz (6.4 KB) · parquet (78.2 KB) — all 223 samples, every field with route and confidence · PRJEB79832_determinations.csv.gz (4.9 KB) — 669 evidence rows