FMT from IPAA donor for chronic pouchitis, Denmark
41 fecal samples from Denmark, from chronic pouchitis patients, an IPAA donor, and healthy donors, studying fecal microbiota transplantation using an IPAA donor; case-series intervention design. machine-written summary
41 samples · 41 runs · DK · Adult · 2025 · 3.04 Gbp / sample · cohort Fecal microbiota transplantation from a healthy po
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 193 sample values (collection date, country, health condition, health condition detail, intervention, subject id) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC12118383 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
Faecal microbiota transplantation design single_arm_before_after · population ibd_or_gi_disease · FMT via enema from IPAA donor for chronic pouchitis
“fecal microbiota transplantation (FMT) from a donor” — abstract:40413728 (study level; per-sample arms are in the intervention column below)
FMT donor → recipient — not resolved
Each row is one person (1 shown); dots are samples at days since that person's first sample.
Evidence of fmt donor recipient structure.
Genera, mean relative abundance over 38 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 41 | 100% | ||||
| country | 41 | 100% | 41 | |||
| health_condition | 29 | 71% | 29 | |||
| subject_id | 12 | 29% | 12 | |||
| collection_date | 41 | 100% | 41 | |||
| intervention | 41 | 100% | 41 | |||
| health_condition_detail | 29 | 71% | 29 |
- Fecal microbiota transplantation from a healthy pouch donor for chronic pouchitis: a proof-of-concept study. 2025 PMID 40413728 PMC12118383 unsure
Archive description
Pouchitis is the most common long-term complication following ileal pouch-anal anastomosis (IPAA) in the surgical treatment of medically refractory ulcerative colitis (UC), with an incidence reported up to 59% in Western countries. Chronic pouchitis presents a challenge for treatment, often leading to surgical removal of the IPAA due to pouch failure. An altered gut microbiota has been associated with IPAA patients with pouchitis compared to those without inflammation. While faecal microbiota transplantation (FMT) has been explored as a treatment for chronic pouchitis in several studies, randomised placebo-controlled trials have not shown a significant benefit of FMT over placebo.6 All studies investigating FMT for pouchitis have utilized a healthy faecal donor with an intact colon. The objective of this proof-of-concept study was to assess the safety, efficacy and microbiome changes of using FMT from a patient with a normal functioning IPAA as a donor in inducing remission in patients with chronic pouchitis.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.description · “long-term complication following ileal pouch-anal anastomosis (IPAA)”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA117708995 | collection_date | 2020-09-17 | R1 | 0.90 | biosample.attribute:collection_date | 2020-09-17 |
| SAMEA117708995 | country | DK | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Denmark |
| SAMEA117709007 | health_condition | ibd_or_gi_disease | R1 | 0.70 | sample.name_rule:DESCRIPTION | DESCRIPTION: Illumina shotgun metagenome of human fecal microbiome from patient |
| SAMEA117709007 | health_condition_detail | patient | R1 | 0.70 | sample.name_rule:DESCRIPTION | DESCRIPTION: Illumina shotgun metagenome of human fecal microbiome from patient |
| SAMEA117708995 | intervention | no_intervention | R1 | 0.70 | sample.name_rule:DESCRIPTION | DESCRIPTION: Illumina shotgun metagenome of human fecal microbiome from pouch donor sample |
| SAMEA117708995 | subject_id | pouch_ipaa_donor | R1 | 0.70 | sample.name_rule:TITLE | TITLE: Asym00000007MP |
Sequencing
41 runs over 41 samples · mean 2.95 Gbp per run (median 3.04 Gbp, total 120.83 Gbp; 41 runs with a base count) · layout PAIRED 41 · platform ILLUMINA 41 · models Illumina NovaSeq 6000 (41) · 93% of runs with a Sandpiper profile · first public 2025-02-19
Authors (5)
Kousgaard SJ first · Dall SM · Albertsen M · Nielsen HL · Thorlacius-Ussing O last
Downloads
PRJEB80556.csv.gz (2.0 KB) · parquet (71.2 KB) — all 41 samples, every field with route and confidence · PRJEB80556_determinations.csv.gz (2.0 KB) — 193 evidence rows