Low birth weight men, exercise/overfeeding intervention, Denmark
130 gut metagenome samples from healthy adult Caucasian males born at low birth weight in Denmark, studying whether 12 weeks of exercise training reverses cardiometabolic effects of 4 weeks of carbohydrate overfeeding. machine-written summary
130 samples · 260 runs · DK · Adult · 2024 · 7.54 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 437 sample values (country, intervention, subject id, timepoint) |
| ✓ Abstract / description | 260 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
43 people have samples in more than one arm.
Controlled / prescribed diet or feeding regimen Exercise / physical-training programme design non_randomized_controlled · population cardiometabolic_other · 12 weeks exercise training after 4 weeks carbohydrate overfeeding
“12 weeks of exercise training” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal
43 of 48 people sampled more than once (125 samples; median 3, up to 3 per person) · follow-up median 4 mo (max 4 mo) · median interval between samples 56 d (time from visit codes mapped to the stated schedule). Schedule stated by the source: “Each subject sampled at baseline (BL), after overfeeding (OF), and after exercise (EX); 3 samples/subject” (time origin: intervention start).
Each row is one person (36 shown of 43); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 128 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 130 | 100% | ||||
| country | 130 | 100% | 130 | |||
| health_condition | 130 | 100% | 130 | |||
| subject_id | 130 | 100% | 130 | |||
| health_condition_detail | 130 | 100% | 130 | |||
| intervention | 130 | 100% | 130 | |||
| timepoint_label | 47 | 36% | 47 |
Archive description
This study aimed to investigate whether 12 weeks of exercise training can revert and/or minimize the deleterious cardiometabolic effects of 4 weeks of carbohydrate overfeeding in individuals born with low birth weight and increased risk of developing type 2 diabetes. This study recruited a total of 48 healthy Caucasian males, born between 1979 and 1980 at full term (gestational weeks 39–41)
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “analysis of the gut microbiome of individuals”
- body site external_curation.infant_catalog · “body_site_call gut/stool”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA115773273 | country | DK | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Denmark |
| SAMEA115773273 | health_condition | healthy_control | R4 | 0.50 | study.description | 48 healthy Caucasian males |
| SAMEA115773273 | health_condition_detail | Healthy individuals at baseline; increased risk of type 2 diabetes due to low birth weight | R4 | 0.50 | study.description | 48 healthy Caucasian males |
| SAMEA115773273 | intervention | no_intervention | R1 | 0.70 | sample.name_rule:alias | HCO_RNEOG-BL |
| SAMEA115773273 | subject_id | RNEOG | R1 | 0.70 | sample.name_rule:alias | HCO_RNEOG-BL |
| SAMEA115773273 | timepoint_label | baseline | R1 | 0.70 | sample.name_rule:alias | HCO_RNEOG-BL |
Sequencing
260 runs over 130 samples · mean 3.85 Gbp per run (median 2.96 Gbp, total 1,001.65 Gbp; 260 runs with a base count) · layout PAIRED 130, SINGLE 130 · platform ILLUMINA 260 · models Illumina HiSeq 4000 (260) · 90% of runs with a Sandpiper profile · first public 2024-11-12
Authors (0)
No author record.
Downloads
PRJEB81698.csv.gz (4.7 KB) · parquet (75.2 KB) — all 130 samples, every field with route and confidence · PRJEB81698_determinations.csv.gz (5.5 KB) — 697 evidence rows