Gut microbiome and frailty in Spanish older adults (case-control)
203 fecal samples from older adults in Spain (64 frail, 139 non-frail), analyzed by 16S rRNA and metagenomic sequencing in a case-control study of gut microbiota links to frailty, sarcopenia, and mobility. machine-written summary
203 samples · 203 runs · ES · Adult · 2025 · 1.21 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 812 sample values (collection date, country, latitude, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 609 sample values (location locality, location site, subject id) · PMC12790095 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 166 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 203 | 100% | ||||
| country | 203 | 100% | 203 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 203 | 100% | 203 | |||
| collection_date | 203 | 100% | 203 | |||
| detailed_location | 203 | 100% | ||||
| latitude | 203 | 100% | 203 | |||
| location_locality | 203 | 100% | 203 | |||
| location_site | 203 | 100% | 203 | |||
| longitude | 203 | 100% | 203 |
- The Role of the Gut Microbiome in the Complex Network of Frailty Syndrome and Associated Comorbidities in Aging. 2026 PMID 41518158 PMC12790095 own_data
Archive description
Frailty is an aging-associated geriatric syndrome characterized by losing muscle mass and strength, reduced endurance, decreased physiological reserves, and cognitive impairment. It is estimated that between 4 and 27% of elders suffer from frailty, being more prone to experience a lower quality of life and a higher risk of death, hospitalization and institutionalization. During aging, the gut microbiota, the second genome, changes and could influence in the health status and trigger physiological disorders.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “The gut microbiome, frailty syndrome”
- body site study.description · “During aging, the gut microbiota, the second”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.description · “is an aging-associated geriatric syndrome characterized by”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMEA117516560 | collection_date | 2022 | R1 | 0.90 | biosample.attribute:collection_date | 2022 |
| SAMEA117516560 | country | ES | R1 | 0.90 | sample.attr.geographic_location_country_and_or_sea | Spain |
| SAMEA117516560 | latitude | 39.4767 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 39.476667 0.374444 |
| SAMEA117516560 | location_locality | Madrid | R3 | 0.70 | paper.fulltext.methods | living in two districts of the city of Madrid |
| SAMEA117516560 | location_site | Seniors-ENRICA-2 cohort | R3 | 0.70 | paper.fulltext.methods | participants in the third wave of the Seniors‐ENRICA‐2 cohort |
| SAMEA117516560 | longitude | 0.3744 | R1 | 0.90 | biosample.attribute:geographic_location_latitude+geographic_location_longitude | 39.476667 0.374444 |
| SAMEA117516560 | subject_id | SAMEA117516560 | R3 | 0.70 | design.one_sample_per_subject:fulltext | Fecal samples were obtained from 203 participants in the Seniors‐ENRICA‐2 cohort |
Sequencing
203 runs over 203 samples · mean 1.23 Gbp per run (median 1.21 Gbp, total 249.63 Gbp; 203 runs with a base count) · layout PAIRED 203 · platform ILLUMINA 203 · models NextSeq 2000 (203) · 82% of runs with a Sandpiper profile · first public 2025-03-21
Authors (6)
Barberá A first · Ortolá R · Sotos-Prieto M · Rodríguez-Artalejo F · Moya A · Ruiz-Ruiz S last
Downloads
PRJEB83322.csv.gz (6.0 KB) · parquet (78.6 KB) — all 203 samples, every field with route and confidence · PRJEB83322_determinations.csv.gz (8.2 KB) — 1,421 evidence rows